Passa al contenuto
Merck
Tutte le immagini(1)

Documenti

SRP8039

Sigma-Aldrich

Irisin

recombinant, expressed in CHO cells, FLAG® tagged, >95% (SDS-PAGE)

Sinonimo/i:

CD121a, Fibronectin type III domain-containing protein 5 (cleaved), Fibronectin type III repeat-containing protein 2 (cleaved)

Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali
Tutte le immagini(1)

About This Item

Numero CAS:
1465928-51-1
Codice UNSPSC:
12352202
NACRES:
NA.32

Ricombinante

expressed in CHO cells

Tag

FLAG® tagged

Saggio

>95% (SDS-PAGE)

Forma fisica

lyophilized

PM

~26 kDa

Confezionamento

pkg of 10 μg

Impurezze

<0.1 EU/μg endotoxin, tested

N° accesso UniProt

Q8NAU1

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

Informazioni sul gene

human ... FNDC5(252995)

Descrizione generale

Irisin is an described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin is cleaved from the type I membrane protein FNDC5 (fibronectin type III domain containing 5). FNDC5 is mainly expressed in the muscles. Low levels of the mRNA are also present in the kidney, liver and lung. The gene encoding irisin is mapped to human chromosome 1p35.1.

Azioni biochim/fisiol

Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone Irisin) and improves systemic metabolism by increasing energy expenditure. It is mainly responsible for the conversion of white fat into brown fat. This conversion enhances metabolic uncoupling and caloric expenditure. Irisin is always associated with beneficial responses of exercise on cellular metabolism. In obese and type 2 diabetic patients, low levels of circulating irisin are characteristic of the adipose tissue and muscle.

Stato fisico

Lyophilized from PBS.

Ricostituzione

Reconstitute with 100 μL deionized water.

Altre note

Irisin (human, aa 16-127 /mouse, aa 29-140) is Flag-tagged at the N-terminus. Irisin has 100% identity betwen mouse, rat, monkey and human.

Note legali

FLAG is a registered trademark of Merck KGaA, Darmstadt, Germany

Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

Possiedi già questo prodotto?

I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

Visita l’Archivio dei documenti

FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise.
Huh JY, et al.
Metabolism, Clinical and Experimental, 61, 1725-1725 (2012)
Common genetic variation in the human FNDC5 locus, encoding the novel muscle-derived 'browning' factor irisin, determines insulin sensitivity.
Staiger H, et al.
PLoS ONE, 8, e61903-e61903 (2013)
Is irisin a human exercise gene?
Timmons JA
Nature, 488, E9-10 (2012)
Irisin is expressed and produced by human muscle and adipose tissue in association with obesity and insulin resistance.
Moreno-Navarrete JM, et al.
The Journal of Clinical Endocrinology and Metabolism, 98, E769-E778 (2013)

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

Contatta l'Assistenza Tecnica.