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Documenti fondamentali

SRP4066

Sigma-Aldrich

FGF-21 human

recombinant, expressed in E. coli, ≥95% (SDS-PAGE)

Sinonimo/i:

FGF21, FGFL, Fibroblast growth factor 21

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About This Item

Codice UNSPSC:
12352202
NACRES:
NA.32

Origine biologica

human

Ricombinante

expressed in E. coli

Saggio

≥95% (SDS-PAGE)

Forma fisica

lyophilized

PM

~19.5 kDa

Confezionamento

pkg of 10 μg

Condizioni di stoccaggio

avoid repeated freeze/thaw cycles

Impurezze

endotoxin, tested

N° accesso NCBI

N° accesso UniProt

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

Informazioni sul gene

human ... FGF21(26291)

Descrizione generale

FGF21 (fibroblast growth factor) belongs to FGF superfamily. It is generated by the liver. The gene is mapped to human chromosome 19q13.33.
Recombinant Human FGF-21 produced in Escherichia coli is a single, non-glycosylated polypeptide chain containing 182 amino acids and having a molecular mass of 19.5kDa.

Azioni biochim/fisiol

FGF21 (fibroblast growth factor) is a hormonal factor which controls glucose homeostasis and energy metabolism. It exhibits anti-diabetic properties by controlling glucose uptake in peripheral tissues. It also possesses autocrine effects in white adipose tissue. FGF21 is present in milk and is needed for intestinal function in the neonate. It is also involved in bone loss. FGF21 exhibits hepatoprotective properties.

Stato fisico

Lyopohilized from 10 mM Tris, pH 7.5 plus 100 mM NaCl.

Ricostituzione

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute the lyophilized product with sterile water at a concentration of 0.1 mg/mL, which can be further diluted into other aqueous solutions.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


Certificati d'analisi (COA)

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Human FGF-21 Is a Substrate of Fibroblast Activation Protein.
Coppage AL
PLoS ONE, 11, e0151269-e0151269 (2016)
Novel locus including FGF21 is associated with dietary macronutrient intake.
Chu AY
Human Molecular Genetics, 22, 1895-1902 (2013)
A Liver-Bone Endocrine Relay by IGFBP1 Promotes Osteoclastogenesis and Mediates FGF21-Induced Bone Resorption.
Wang X
Cell Metabolism, 22, 811-824 (2015)
Fibroblast Activation Protein Cleaves and Inactivates Fibroblast Growth Factor 21.
Dunshee DR
The Journal of Biological Chemistry, 291, 5986-5996 (2016)
Wen-Pin Huang et al.
Journal of cellular and molecular medicine, 26(8), 2451-2461 (2022-03-22)
Circulating endothelial progenitor cells (EPCs), which function in vascular repair, are the markers of endothelial dysfunction and vascular health. Fibroblast growth factor 21 (FGF21), a liver-secreted protein, plays a crucial role in glucose homeostasis and lipid metabolism. FGF21 has been reported

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