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SRP0330

Sigma-Aldrich

BTK active human

recombinant, expressed in baculovirus infected Sf9 cells, ≥80% (SDS-PAGE)

Sinonimo/i:

AGMX1, BPK, Bruton agammaglobulinemia tyrosine kinase, PSCTK1

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About This Item

Numero CAS:
391968-46-0
Codice UNSPSC:
12352204
NACRES:
NA.32

Origine biologica

human

Ricombinante

expressed in baculovirus infected Sf9 cells

Saggio

≥80% (SDS-PAGE)

Forma fisica

aqueous solution

PM

106 kDa

Confezionamento

pkg of 10 μg

tecniche

activity assay: suitable
inhibition assay: suitable

N° accesso NCBI

NM_000061

N° accesso UniProt

Q06187

Condizioni di spedizione

dry ice

Temperatura di conservazione

−70°C

Informazioni sul gene

human ... BTK(695)

Descrizione generale

Human BTK (GenBank Accession No. NM_000061), full length with N-terminal GST-tag, MW= 106 kDa, expressed in a Baculovirus infected Sf9 cell expression system.

Applicazioni

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

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M Liljeroos et al.
Cellular signalling, 19(3), 625-633 (2006-10-06)
Lipoteichoic acid (LTA) of Gram-positive bacteria initiates innate immune responses via Toll-like receptor-2 (TLR2), resulting in the activation of intracellular signaling and production of inflammatory cytokines in macrophages. Although Bruton's tyrosine kinase (Btk) is biologically important molecule implicated in immune
L L Ong et al.
SLAS discovery : advancing life sciences R & D, 25(2), 176-185 (2019-11-12)
Protein kinases are intensely studied mediators of cellular signaling. While traditional biochemical screens are capable of identifying compounds that modulate kinase activity, these assays are limited in their capability of predicting compound behavior in a cellular environment. Here, we aim
Ximena Zottig et al.
The protein journal, 36(6), 478-488 (2017-10-05)
Recent investigations of Aneurinibacillus thermoaerophilus strains have allowed identification of a unique solvent tolerant lipase, distinct from known lipases. This work reports the expression and purification of this lipase (LipAT) and the first characterization of its structure and temperature and
Niklas Feldhahn et al.
The Journal of experimental medicine, 201(11), 1837-1852 (2005-06-09)
Pre-B cells undergo apoptosis unless they are rescued by pre-B cell receptor-dependent survival signals. We previously showed that the BCR-ABL1 kinase that is expressed in pre-B lymphoblastic leukemia bypasses selection for pre-B cell receptor-dependent survival signals. Investigating possible interference of
Miran Rada et al.
Oncotarget, 8(63), 106639-106647 (2018-01-02)
p53 is a tumour suppressor that is activated in response to various types of stress. It is regulated by a complex pattern of over 50 different post-translational modifications, including ubiquitination by the E3 ligase MDM2, which leads to its proteasomal
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