Intepirdine (SB-742457) is a brain blood barrier penetrant, orally available, potent and selective serotonin receptor 6 (5-HT6) receptor antagonist that potentiate cognitive and the behavioral abnormalities of AD in laboratory set up. Intepirdine has failed to demonstrate statistically significant impact on cognition or dementia in phase III trials. Intepirdine promotes satiety.
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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5-HT6 receptor antagonists as novel cognitive enhancing agents for Alzheimer's disease
Neurotherapeutics, 5(3), 458-469 (2008)
The 5-HT?C receptor agonist, lorcaserin, and the 5-HT? receptor antagonist, SB-742457, promote satiety; a microstructural analysis of feeding behaviour
Psychopharmacology, 233(3), 417-424 (2016)
5-HT6 receptor agonist and antagonist improve memory impairments and hippocampal BDNF signaling alterations induced by MK-801
Brain Research, 1722, 146375-146375 (2019)
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