SML3330

MRK-560

≥98% (HPLC)

• Sinonimo/i: MRK 560, MRK560, N-[cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide
• Formula empirica (notazione di Hill): C₁₉H₁₇ClF₅NO₄S₂
• Numero CAS: 677772-84-8
• Peso molecolare: 517.92
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD09970622
• Assay: ≥98% (HPLC)
• Form: powder

Proprietà

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: −20°C
• SMILES string: FC(F)(F)[S](=O)(=O)N[C@@H]1CC[C@@](CC1)([S](=O)(=O)c3ccc(cc3)Cl)c2c(ccc(c2)F)F
• InChI: 1S/C19H17ClF5NO4S2/c20-12-1-4-15(5-2-12)31(27,28)18(16-11-13(21)3-6-17(16)22)9-7-14(8-10-18)26-32(29,30)19(23,24)25/h1-6,11,14,26H,7-10H2/t14-,18+
• InChI key: WDZVWDXOIGQJIO-UJKQEGAGSA-N

Descrizione

Biochem/physiol Actions

Brain-penetrant, orally active, highly potent and selective gamma-secretase inhibitor with CNS Aβ40-lowering efficacy in mice and rats in vivo.

MRK-560 is a brain-penetrant, orally active, highly potent and selective gamma-secretase inhibitor (GSI; IC50 = 0.65 nM by SH-SY5Y cellular γ-secretase substrate A4CTF breakdown assay) with little inhibitory potency against a panel of 171 enzymes/receptors. MRK-560 blocks Aβ40 & Aβ42 production with similar potency in SH-SY5Y cultures (IC50 <0.5 nM) and lowers CNS Aβ40 in rats (brain & SCF ED50 in 8h = 6 & 10 mg/kg po.) and APP-YAC mice (brain ED50 in 4h <3 mg/kg po.) in vivo

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Parola di avvertenza: Warning
• Codici di pericolo: H315,H319
• Avvertenze di sicurezza: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2
• Classe di stoccaggio: 11 - Combustible Solids
• Che succede?: WGK 3
• Punto di infiammabilità (°F): Not applicable
• Punto di infiammabilità (°C): Not applicable