SML3254

Aloperine

≥98% (HPLC)

• Sinonimo/i: Alop1 compound,(7-alpha,9-alpha)-9-De-2-piperidinyl-16,17-didehydro-ormosanine, ALO, (6R,6aR,13R,13aS)-1,3,4,6,6a,7,8,9,10,12,13,13a-Dodecahydro-6,13-methano-2H-dipyrido[1,2-a:3′,2′-e]azocine, Ormosanine
• Formula empirica (notazione di Hill): C₁₅H₂₄N₂
• Numero CAS: 56293-29-9
• Peso molecolare: 232.36
• Numero MDL: MFCD00468086
• Codice UNSPSC: 12352107
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Stato: powder
• Attività ottica: [α]/D 73 to 89°, c = 0.5 g/mL in ethanol
• Colore: white to beige
• Punto di fusione: 67-72 °C
• Solubilità: DMSO: 2 mg/mL, clear
• Temperatura di conservazione: −20°C
• Stringa SMILE: [H][C@]12CN3CCCC[C@]3([H])[C@]([H])(C1)C=C4CCCN[C@@]24[H]
• InChI: 1S/C15H24N2/c1-2-7-17-10-13-9-12(14(17)5-1)8-11-4-3-6-16-15(11)13/h8,12-16H,1-7,9-10H2/t12-,13+,14+,15+/m0/s1; SKOLRLSBMUGVOY-GBJTYRQASA-N

Descrizione

Descrizione generale

Aloperine is a quinolizidine-type alkaloid found in the seeds and leaves of the herbal plant, Sophora alopecuroides L.[1] It possesses antiviral, anticancer, antioxidant, and anti-inflammatory activity.[2] Aloperine exhibits antifibrotic activity in mouse models of pulmonary fibrosis, and anticancer activity in human osteosarcoma and thyroid cancer cells. It also exhibits neuroprotective effects against oxidative stress in early brain injury, and antiviral activity as a human immunodeficiency virus-1 (HIV-1) entry inhibitor.[1] Aloperine also has the ability to inhibit migration and invasion of liver cancer cells, as well as disrupt the cell cycle, and mitigate cell growth at various phases. It can hinder the phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/Akt/mTOR) signaling pathway.[2]

Applicazioni

Aloperine may be used to study its effects on allergic airway inflammation in the murine asthma model and to compare its anti-asthmatic activity.[3]

Azioni biochim/fisiol

Alkaloid with antiviral, anticancer, antioxidant, and anti-inflammatory activity

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H302
• Consigli di prudenza: P264 - P270 - P301 + P312 - P501
• Classi di pericolo: Acute Tox. 4 Oral
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable