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SML0045

Sigma-Aldrich

Salvianolic acid A hydrate

≥98% (HPLC)

Sinonimo/i:

Dan phenolic acid A hydrate

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About This Item

Formula empirica (notazione di Hill):
C26H22O10 · xH2O
Numero CAS:
96574-01-5
Peso molecolare:
494.45 (anhydrous basis)
Numero MDL:
MFCD20527310
Codice UNSPSC:
12352200
ID PubChem:
329825115
NACRES:
NA.77

Saggio

≥98% (HPLC)

Forma fisica

powder

Colore

yellow

Solubilità

H2O: ≥19 mg/mL

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

Stringa SMILE

O.OC(=O)[C@@H](Cc1ccc(O)c(O)c1)OC(=O)\C=C\c2ccc(O)c(O)c2\C=C\c3ccc(O)c(O)c3

InChI

1S/C26H22O10.H2O/c27-18-7-2-14(11-21(18)30)1-6-17-16(4-9-20(29)25(17)33)5-10-24(32)36-23(26(34)35)13-15-3-8-19(28)22(31)12-15;/h1-12,23,27-31,33H,13H2,(H,34,35);1H2/b6-1+,10-5+;/t23-;/m1./s1
XFUSRNNWIRPEDG-FYLUTCCGSA-N

Applicazioni

Salvianolic acid A hydrate may be used in cell signaling studies.
Salvianolic acid A hydrate has been used as rosmarinic acid derivative for the inhibition of DNA polymerase e in human cell lines.

Azioni biochim/fisiol

Salvianolic acid A acts as scavengers of reactive oxygen species, reduces the adherence of leukocytes to endothelial cells, inhibits matrix metalloproteinases and inflammation. It has cardioprotective effects as it suppresses apoptosis, reduces lipid peroxidation in damaged cardiac tissue and decreases the leakage of lactic acid dehydrogenase.
Salvianolic acid A is cell protective antioxidant originally isolated from Salvia. It has been found to attenuate PDGF-induced ROS formation in hepatic stellate cells and protected against isoproterenol-induced myocardial damage in rats.

Codice della classe di stoccaggio

13 - Non Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Salvianolic acid A phyproof® Reference Substance

PHL80530

Salvianolic acid A

Salvianolic acid D phyproof® Reference Substance

PHL83540

Salvianolic acid D

Salvianolic acid B United States Pharmacopeia (USP) Reference Standard

USP

1609818

Salvianolic acid B

Heng-ai Zhang et al.
Biochemical and biophysical research communications, 421(3), 479-483 (2012-04-21)
Salvianolic acid A (Sal A) is a polyphenol extracted from the root of the Salvia miltiorrhiza bunge. Hydrogen peroxide (H(2)O(2)) is a major reactive oxygen species (ROS), which has been implicated in stroke and other neurodegenerative diseases, including Alzheimer's disease
Xiao-Juan Lai et al.
Fitoterapia, 82(6), 883-888 (2011-05-18)
Salviae miltiorrhizae is one of the most commonly used herbal plants in the treatment of numerous ailments including cardiovascular diseases for hundreds of years. According to the theory of traditional Chinese herbal medicine, S. miltiorrhizae is always used in combination
Li Zhang et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 36(19), 2603-2609 (2012-01-17)
Salvianolic acid A is a water-soluble component from Danshen, which is frequently used in traditional Chinese medicine. High performance liquid chromatography was often used to analyze content of salvianolic acid A. The yield of salvianolic acid A increased by the
Jing Wang et al.
Folia neuropathologica, 59(1), 50-66 (2021-05-11)
More than 50 million people are affected by traumatic brain injury (TBI) each year around the world, and nearly half of the population worldwide will have one or more TBI(s) in their lifetime. And in 2017, more than 1.39 billion
Baohong Jiang et al.
PloS one, 8(3), e59621-e59621 (2013-03-28)
Cardiac fibrosis is a deleterious consequence of hypertension which may further advance to heart failure and increased matrix metalloproteinase-9 (MMP-9) contributes to the underlying mechanism. Therefore, new therapeutic strategies to attenuate the effects of MMP-9 are urgently needed. In the
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