MAPT (microtubule associated protein tau) is located on human chromosome 17q21.3. This gene is expressed in neurons but is most prominent in axons.
Immunogeno
The antiserum was produced against synthesized peptide derived from human Tau around the phosphorylation site of Thr205.
Immunogen Range: 491-540
Azioni biochim/fisiol
MAPT (microtubule associated protein tau) participates in the pathology of Alzheimer′s disease (AD). It helps in the assembly and maintenance of microtubule structures. Removal of MAPT results in developmental delay and learning disability.
Caratteristiche e vantaggi
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Stato fisico
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Previously, we revealed that brain Ang-(1-7) deficiency was involved in the pathogenesis of sporadic Alzheimer's disease (AD). We speculated that restoration of brain Ang-(1-7) levels might have a therapeutic effect against AD. However, the relatively short duration of biological effect
Microdeletion encompassing MAPT at chromosome 17q21. 3 is associated with developmental delay and learning disability.
Linkage disequilibrium and association of MAPT H1 in Parkinson disease
Skipper L, et al.
American Journal of Human Genetics, 75(4), 669-677 (2004)
The H1c haplotype at the MAPT locus is associated with Alzheimer's disease
Myers AJ, et al.
Human Molecular Genetics, 14(16), 2399-2404 (2005)
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