SAB4501406
Anti-Nuclear Receptor NR4A1 antibody produced in rabbit
affinity isolated antibody
Sinonimo/i:
Early response protein NAK1, Nuclear receptor subfamily 4 group A member 1, Orphan nuclear receptor HMR, ST-59, TR3 orphan receptor
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100 μG
459,00 €
459,00 €
Per informazioni sulla disponibilità, contatta il Servizio Clienti.
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Cambia visualizzazione
100 μG
459,00 €
About This Item
Codice UNSPSC:
12352203
NACRES:
NA.41
459,00 €
Per informazioni sulla disponibilità, contatta il Servizio Clienti.
Prodotti consigliati
Origine biologica
rabbit
Coniugato
unconjugated
Forma dell’anticorpo
affinity isolated antibody
Tipo di anticorpo
primary antibodies
Clone
polyclonal
Stato
buffered aqueous solution
PM
antigen 64 kDa
Reattività contro le specie
rat, human, mouse
Concentrazione
~1 mg/mL
tecniche
ELISA: 1:10000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
N° accesso NCBI
N° accesso UniProt
Condizioni di spedizione
wet ice
Temperatura di conservazione
−20°C
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
human ... NR4A1(3164)
Categorie correlate
Descrizione generale
Nuclear receptor subfamily 4 group A member1 (NR4A1) is an orphan receptor that belongs to the nuclear hormone receptor superfamily. The NR4A1 gene is mapped to human chromosome 12q13.13. Structurally, NR4A1 comprises an N-terminal AB region, DNA binding domain (DBD), and a C-terminal ligand-binding domain (LBD). Anti-Nuclear Receptor NR4A1 antibody detects endogenous levels of total Nuclear Receptor NR4A1 protein.
Immunogeno
The antiserum was produced against synthesized peptide derived from human Nuclear Receptor NR4A1.
Immunogen Range: 317-366
Immunogen Range: 317-366
Azioni biochim/fisiol
Nuclear receptor subfamily 4 group A member1 (NR4A1) participates in gene expression regulation in the hypothalamic-pituitary-adrenal axis (HPA) especially those related to inflammation and steroidogenesis. The levels of NR4A1 are downregulated in metastatic melanoma, myelogenous leukemia, and follicular thyroid carcinoma. An elevated expression of NR4A1 is observed in type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) in mouse models. Dysfunction of NR4A1 is correlated to energy balance and also the events of metabolic pathways including carbohydrates and lipids. NR4A1 contributes to arterial vessel cell wall damage. It regulates tumor cell proliferation, migration, and invasion. NR4A1 may serve as a biomarker for depression and other psychiatric disorders.
Caratteristiche e vantaggi
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Stato fisico
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
nwg
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
Transcripts of orphan nuclear receptor (NR4A1) & potassium channel (KCNK17) genes as new potential biomarkers for depression
Dmitrzak-Weglarz M, et al.
Meta Gene null
Lei Zhang et al.
Journal of diabetes research, 2018, 9363461-9363461 (2018-07-18)
Orphan nuclear receptor 4A1 (NR4A1) is a transcriptional factor of the nuclear orphan receptor (NR4A) superfamily that has sparked interest across different research fields in recent years. Several studies have demonstrated that ligand-independent NR4A1 is an immediate-early response gene and
Stephen Safe et al.
The Journal of steroid biochemistry and molecular biology, 157, 48-60 (2015-04-29)
The orphan nuclear receptors NR4A1, NR4A2 and NR4A3 are immediate early genes induced by multiple stressors, and the NR4A receptors play an important role in maintaining cellular homeostasis and disease. There is increasing evidence for the role of these receptors
K D Senali Abayratna Wansa et al.
The Journal of biological chemistry, 277(36), 33001-33011 (2002-06-26)
Nur77/NR4A1 is an "orphan member" of the nuclear hormone receptor superfamily. Nur77 and its close relatives Nurr1 and NOR-1 bind as monomers to a consensus binding site, the nerve growth factor induced protein I-B (NGFI-B)-binding response element (NBRE). The Nur77/NURR1/NOR1
Shaoxi Liao et al.
Genes, chromosomes & cancer, 51(12), 1067-1078 (2012-08-14)
Only a minority of intraductal carcinomas of the breast give rise to stromally invasive disease. We microdissected 206 paraffin blocks representing 116 different cases of low-grade ductal carcinoma in situ (DCIS). Fifty-five were pure DCIS (PD) cases without progression to
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