SAB4500156
Anti-PLK2 antibody produced in rabbit
affinity isolated antibody
Sinonimo/i:
PLK-2, Polo-like kinase 1, Serine/threonine-protein kinase SNK, Serum-inducible kinase
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100 μG
390,00 €
390,00 €
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Cambia visualizzazione
100 μG
390,00 €
About This Item
Codice UNSPSC:
12352203
NACRES:
NA.41
390,00 €
Per informazioni sulla disponibilità, contatta il Servizio Clienti.
Prodotti consigliati
Origine biologica
rabbit
Livello qualitativo
Coniugato
unconjugated
Forma dell’anticorpo
affinity isolated antibody
Tipo di anticorpo
primary antibodies
Clone
polyclonal
Stato
buffered aqueous solution
PM
antigen 78 kDa
Reattività contro le specie
rat, human, mouse
Concentrazione
~1 mg/mL
tecniche
ELISA: 1:40000
western blot: 1:500-1:1000
N° accesso NCBI
N° accesso UniProt
Condizioni di spedizione
wet ice
Temperatura di conservazione
−20°C
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
human ... PLK2(10769)
Descrizione generale
Anti-PLK2 Antibody detects endogenous levels of total PLK2 protein.
Polo-like kinases 2 (PLK2) is a member of the serine-threonine kinases family. The PLK2 gene is mapped to human chromosome 5q11.2. PLK2 comprises a C-terminal polo-box domain (PBD) devoid of catalytic activity and an N-terminal kinase domain.
Immunogeno
The antiserum was produced against synthesized peptide derived from human PLK2.
Immunogen Range: 291-340
Immunogen Range: 291-340
Applicazioni
Anti-PLK2 antibody produced in rabbit has been used in western blotting(1:1000) (1:5000)[1]
Azioni biochim/fisiol
Polo-like kinase 2 (PLK2) participates in regulating centriole duplication, cell death, and cell cycle. It also mediates the spine-associated RapGAP (SPAR) degradation via the ubiquitin-proteasome pathway, thereby regulating synaptic plasticity. Mutations in the PLK2 gene are observed in colorectal cancers. The PLK2 gene knockdown leads to defects in centriole duplication.
Caratteristiche e vantaggi
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Stato fisico
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
nwg
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
Ju Hee Kim et al.
Proteins, 83(7), 1201-1208 (2015-04-08)
Polo-like kinases (Plks) are the key regulators of cell cycle progression, the members of which share a kinase domain and a polo-box domain (PBD) that serves as a protein-binding module. While Plk1 is a promising target for antitumor therapy, Plk2
Frameshift mutation and loss of expression of PLK2, a serine/threonine kinase-encoding gene, in colorectal cancers.
Ju Hwa Lee et al.
Pathology, research and practice, 213(8), 1019-1020 (2017-07-13)
Zhiqiang Gao et al.
Biochemistry and cell biology = Biochimie et biologie cellulaire, 99(4), 403-413 (2020-12-03)
Neuronal injury induced by cerebral ischemia poses a serious health risk globally, and there is no effective clinical therapy. This study was performed to investigate the role of transcription factor AP-2 alpha (TFAP2A) in cerebral ischemia, and the underlying mechanisms
Association of TERT promoter mutations with telomerase expression in melanoma.
Seungjae Lee et al.
Pigment cell & melanoma research, 29(3), 391-393 (2016-03-02)
Jaerak Chang et al.
The EMBO journal, 29(14), 2395-2406 (2010-06-10)
Control of centrosome duplication is tightly linked with the progression of the cell cycle. Recent studies suggest that the fundamental process of centriole duplication is evolutionally conserved. Here, we identified centrosomal P4.1-associated protein (CPAP), a human homologue of SAS-4, as
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