Protein tyrosine phosphatase, receptor type C (PTPRC) or leucocyte common antigen CD45 is expressed on T-cells and is found in multiple isoforms. The extracellular domain of the protein is predicted to have an amino-terminal mucin-like segment, a cysteine-rich domain and three fibronectin type 3 domains. The gene encoding this protein is localized on human chromosome 1q31.3.
Applicazioni
ANTI-CD45(C-TERMINAL) antibody produced in rabbit has been used in Western blotting.
Azioni biochim/fisiol
Protein tyrosine phosphatase, receptor type C (PTPRC) or leucocyte common antigen CD45 acts as a protein tyrosine phosphatase in leucocyte signaling. It has a role in flow cytometric diagnostics in leukemia. By dephosphorylation of Src kinases, the protein acts as a regulator of antigen receptor signaling in T and B cells. As a negative regulator of janus kinases, CD45 inhibits cytokine receptor signaling.
Stato fisico
Supplied in PBS with 0.09% (W/V) sodium azide
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Replication of association of the PTPRC gene with response to anti?tumor necrosis factor therapy in a large UK cohort*
Darren Plant, et al.
Arthritis & Rheumatology (Hoboken, N.J.) (2011)
Clinicoradiological characteristics, management and prognosis of primary myeloid sarcoma of the central nervous system: A report of four cases
Bao Yang, et al.
Oncology Letters (2017)
CD45RO+ Memory T Lymphocytes ? a Candidate Marker for TNM-Immunoscore in Squamous Non?Small Cell Lung Cancer1
Erna-Elise Paulsen, et al.
Neoplasia (2015)
High CD45 surface expression determines relapse risk in children with precursor B-cell and T-cell acute lymphoblastic leukemia treated according to the ALL-BFM 2000 protocol
Gunnar Cario, et al.
Haematologica (2014)
Initiation of T cell signaling by CD45 segregation at `close-contacts?
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