SAB1300086
Anti-SOST (N-term) antibody produced in rabbit
Ig fraction of antiserum, buffered aqueous solution
Sinonimo/i:
Anti-CDD, Anti-DAND6, Anti-SOST1, Anti-VBCH
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About This Item
Codice UNSPSC:
12352203
NACRES:
NA.41
Prodotti consigliati
Origine biologica
rabbit
Coniugato
unconjugated
Forma dell’anticorpo
Ig fraction of antiserum
Tipo di anticorpo
primary antibodies
Clone
polyclonal
Forma fisica
buffered aqueous solution
Reattività contro le specie
mouse, human
tecniche
immunohistochemistry: 1:50-1:100
indirect ELISA: 1:1000
western blot: 1:100-1:500
N° accesso NCBI
N° accesso UniProt
Condizioni di spedizione
dry ice
Temperatura di conservazione
−20°C
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
human ... SOST(50964)
Descrizione generale
SOST (sclerostin) gene codes for the protein sclerostin which is predominantly secreted by the osteocytes. The encoded protein is predominantly expressed in human woven and lamellar bone and mineralizing chondrocytes.
Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.
Immunogeno
SOST (NP_079513, 12-42)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human SOST.
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human SOST.
Applicazioni
Anti-SOST (N-term) antibody produced in rabbit has been used in immunohistochemistry.
Azioni biochim/fisiol
Sclerostin regulates bone remodeling in presence of mechanical stimulation. It has an inhibitory effect on the activation of osteoblasts by inducing phosphorylation and degradation of β-catenin. It downregulates bone formation and induces bone resorption. Mutation in this gene causes hyperostosis and leads to Van Buchem disease or sclerosteosis. Increased bone formation and enhanced healing of bone defects are observed upon selective deletion of the SOST gene in mice model. Sclerostin, a glycoprotein, is involved in vascular calcification. It might be associated with cardiovascular disorders.
Stato fisico
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
nwg
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Certificati d'analisi (COA)
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
Francesca Marta Elli et al.
Frontiers in endocrinology, 15, 1296886-1296886 (2024-06-03)
The dysregulation of cell fate toward osteoprecursor cells associated with most GNAS-based disorders may lead to episodic de novo extraskeletal or ectopic bone formation in subcutaneous tissues. The bony lesion distribution suggests the involvement of abnormal differentiation of mesenchymal stem
Abdul Rashid Qureshi et al.
Kidney international, 88(6), 1356-1364 (2015-09-04)
Sclerostin, an osteocyte-derived inhibitor of bone formation, is linked to mineral bone disorder. In order to validate its potential as a predictor of vascular calcification, we explored associations of circulating sclerostin with measures of calcification in 89 epigastric artery biopsies
Wen Liu et al.
Open biology, 9(5), 180262-180262 (2019-05-16)
Osteocytes secrete the glycoprotein sclerostin to inhibit bone formation by osteoblasts, but how sclerostin production is regulated in osteocytes remains unclear. Here, we show that tuberous sclerosis complex 1 (TSC1) in osteocytes promotes sclerostin secretion through inhibition of mechanistic target
Asiri R Wijenayaka et al.
The Journal of steroid biochemistry and molecular biology, 164, 369-373 (2015-12-23)
The osteocyte expressed gene SOST encodes sclerostin, a potent negative regulator of bone formation and inducer of bone resorption. We have recently demonstrated that the human SOST gene is positively regulated in response to 1α,25-dihydroxyvitamin D
Yusuke Inagaki et al.
Histopathology, 69(3), 470-478 (2016-02-21)
To assess the immunophenotypic and mRNA expression of sclerostin in human skeletal tissues and in a wide range of benign and malignant bone tumours and tumour-like lesions. Sclerostin expression was evaluated by immunohistochemistry and quantitative polymerase chain reaction (PCR). In
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