SAB1104559
Anti-NUPR1 (47-60) antibody produced in rabbit
IgG fraction of antiserum
Sinonimo/i:
Anti-COM1, Anti-Nuclear protein, transcriptional regulator, 1
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About This Item
Codice UNSPSC:
12352203
NACRES:
NA.41
Prodotti consigliati
Origine biologica
rabbit
Coniugato
unconjugated
Forma dell’anticorpo
IgG fraction of antiserum
Tipo di anticorpo
primary antibodies
Clone
polyclonal
Stato
buffered aqueous solution
PM
antigen predicted mol wt ~9 kDa
Reattività contro le specie
human
tecniche
western blot: 1:500-1:2,000
N° accesso UniProt
Condizioni di spedizione
dry ice
Temperatura di conservazione
−20°C
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
human ... NUPR1(26471)
Descrizione generale
The NUPR1 (nuclear protein 1, transcriptional regulator) gene is mapped to human chromosome 16p11.2 and encodes a chromatin remodeling protein of 8.8 KDa.
Immunogeno
synthetic peptide corresponding to amino acids 47-60 of human NUPR1
Applicazioni
Anti-NUPR1 (47-60) antibody produced in rabbit has been used in western blot analysis.
Azioni biochim/fisiol
Nupr1 (nuclear protein 1, transcriptional regulator) is a stress response factor, induced by lipopolysaccharides, CCl4, starvation, cell cycle arrest and other protein stimuli. NUPR1 is associated with tumor cell proliferation, metastasis and apoptosis, also regulates entosis, matrix remodeling and autophagy. It serves as a substrate for protein kinase A. Overexpression of this gene is observed in glioblastoma and hepatocellular carcinoma. The protein function is tissue specific and differs at molecular level. It can act as a tumor suppressor or inducer.
Stato fisico
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Codice della classe di stoccaggio
12 - Non Combustible Liquids
Classe di pericolosità dell'acqua (WGK)
WGK 2
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
Pivotal role of the chromatin protein Nupr1 in Kras-induced senescence and transformation.
Grasso D, et al.
Scientific Reports, 5, 17549-17549 (2015)
Priscila R Andrade et al.
PLoS neglected tropical diseases, 13(7), e0007589-e0007589 (2019-07-26)
The initial interaction between a microbial pathogen and the host immune response influences the outcome of the battle between the host and the foreign invader. Leprosy, caused by the obligate intracellular pathogen Mycobacterium leprae, provides a model to study relevant
A liver stress-endocrine nexus promotes metabolic integrity during dietary protein dilution.
Maida A, et al.
The Journal of Clinical Investigation, 126(9), 3263-3278 (2016)
Knockdown of NUPR1 inhibits the proliferation of glioblastoma cells via ERK1/2, p38 MAPK and caspase-3.
Li J, et al.
Journal of Neuro-Oncology, 132(1), 15-26 (2017)
Hexavalent chromium (Cr (VI)) down-regulates acetylation of histone H4 at lysine 16 through induction of stressor protein Nupr1.
Chen D, et al.
PLoS ONE, 11(6), e0157317-e0157317 (2016)
Filtri attivi
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