S9564
Amyloid Precursor Protein α, Secreted human
>90% (SDS-PAGE), recombinant, expressed in E. coli (N-terminal histidine tagged), buffered aqueous solution
Sinonimo/i:
sAPPα
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25 μG
755,00 €
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Cambia visualizzazione
25 μG
755,00 €
About This Item
Prodotti consigliati
Descrizione generale
Applicazioni
Azioni biochim/fisiol
Amyloid precursor protein α is an α-secretase-cleaved soluble protein that has been shown to have neuroprotective properties. It is derived from amyloid precursor protein. The protein consists of 612 amino acids. Several G protein-coupled receptors are known to activate α-secretase-dependent processing of APP. It has neuroprotective, neurogenic and neurotrophic functions. Amyloid precursor protein a also stimulates gene expression and protein expression.[6]
Stato fisico
Solution 0.2 μm filtered, in phosphate buffered saline, pH 7.4.
Nota sulla preparazione
Expressed as a soluble protein and purified under non-denaturing conditions.
Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
nwg
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
C U Pietrzik et al.
Proceedings of the National Academy of Sciences of the United States of America, 95(4), 1770-1775 (1998-03-21)
In various species, thyrotropin (TSH) is known to stimulate both differentiation and proliferation of thyroid follicle cells. This cell type has also been shown to express members of the Alzheimer amyloid precursor (APP) protein family and to release the secretory
Soluble ?-amyloid Precursor Protein Alpha Binds to p75 Neurotrophin Receptor to Promote Neurite Outgrowth
Noriko Hasebe
PLoS ONE (2013)
Soluble b-amyloid Precursor Protein Alpha Binds to p75 Neurotrophin Receptor to
Hasebe N
PLoS ONE (2013)
In vivo BACE1 inhibition leads to brain A?
lowering and increased a-secretase processing of
APP without effect on Neuregulin-1
lowering and increased a-secretase processing of
APP without effect on Neuregulin-1
Sethu Sankaranarayanan
American Society for Engineering Education (2018)
S W Barger et al.
Journal of neurochemistry, 76(3), 846-854 (2001-02-07)
Microglial activation as part of a chronic inflammatory response is a prominent component of Alzheimer's disease. Secreted forms of the beta-amyloid precursor protein (sAPP) previously were found to activate microglia, elevating their neurotoxic potential. To explore neurotoxic mechanisms, we analyzed
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