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S8260

Sigma-Aldrich

Salbutamol

≥96% (GC), powder, β2 adrenoceptor agonist

Sinonimo/i:

α-[(tert-Butylamino)methyl]-4-hydroxy-m-xylene-α,α′-diol, Albuterol

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About This Item

Formula empirica (notazione di Hill):
C13H21NO3
Numero CAS:
18559-94-9
Peso molecolare:
239.31
Beilstein:
6405698
Numero CE:
242-424-0
Numero MDL:
MFCD00148978
Codice UNSPSC:
12352200
ID PubChem:
24278712
NACRES:
NA.77

product name

Salbutamol,

Solubilità

methanol: complete 50 mg/ml, clear, colorless to yellow

Ideatore

GlaxoSmithKline

Stringa SMILE

CC(C)(C)NCC(O)c1ccc(O)c(CO)c1

InChI

1S/C13H21NO3/c1-13(2,3)14-7-12(17)9-4-5-11(16)10(6-9)8-15/h4-6,12,14-17H,7-8H2,1-3H3
NDAUXUAQIAJITI-UHFFFAOYSA-N

Informazioni sul gene

human ... ADRB2(154)

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Applicazioni

Salbutamol was administered to primate model to study the bronchoconstriction in chronic allergic asthma.20 Salbutamol was used as a standard for rapid pharmacokinetic screening of human plasma samples using HPLC.21

Azioni biochim/fisiol

Salbutamol is a β2 adrenoceptor agonist with short acting bronchodilation and anti-inflammatory effects. It relaxes the airway smooth muscles and inhibits bronchoconstriction induced by adenosine-5′ -monophosphate (AMP).1 Salbutamol is particularly effective in treatment of asthma as it provides immediate relief.2
β2-adrenoceptor agonist

Caratteristiche e vantaggi

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Applicazioni

N° Catalogo
Descrizione
Determinazione del prezzo

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H302,H317,H319,H412

Classi di pericolo

Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Skin Sens. 1B

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

Certificati d'analisi (COA)

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Huib A M Kerstjens et al.
The Lancet. Respiratory medicine, 3(5), 367-376 (2015-02-16)
In patients with severe asthma, tiotropium improves lung function and exacerbation risk when added to high-dose inhaled corticosteroids plus long-acting β2 agonists. We aimed to assess the safety and efficacy of tiotropium in patients with moderate asthma who were symptomatic
James Fingleton et al.
The Journal of allergy and clinical immunology, 136(3), 601-609 (2015-03-10)
Asthma and chronic obstructive pulmonary disease (COPD) are heterogeneous disorders encompassing different phenotypes of airflow obstruction, which might differ in their response to treatment. The aim of this study was to determine distinct phenotypes comprising the syndromes of asthma and
Rachel A Matt et al.
Frontiers in molecular biosciences, 10, 1214102-1214102 (2023-09-04)
Noradrenergic projections from the brainstem locus coeruleus drive arousal, attentiveness, mood, and memory, but specific adrenoceptor (AR) function across the varied brain cell types has not been extensively characterized, especially with agonists. This study reports a pharmacological analysis of brain
Anna Zaia Carolina Rodrigues et al.
Molecular and cellular neurosciences, 95, 59-70 (2019-02-15)
Increasing evidence indicates that, first, the sympathetic nervous system interacts extensively with both vasculature and skeletal muscle fibers near neuromuscular junctions (NMJs) and, second, its neurotransmitter, noradrenaline, influences myofiber molecular composition and function and motor innervation. Since sympathomimetic agents have
Kirti Singh et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 168, 115763-115763 (2023-10-23)
Asthma and other airway obstructive disorders are characterized by heightened inflammation and excessive airway epithelial cell reactive oxygen species (ROS), which give rise to a highly oxidative environment. After decades of use, β2-adrenergic receptor (β2AR) agonists remain at the forefront
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Chromatograms

application for HPLC

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