PZ0188

PF-3644022 hydrate

≥98% (HPLC)

• Sinonimo/i: (10R)-9,10,11,12-tetrahydro-10-methyl-3-(6-methyl-3-pyridinyl)-8H-[1,4]diazepino[5′,6′:4,5]thieno[3,2-f]quinolin-8-one hydrate
• Formula empirica (notazione di Hill): C₂₁H₁₈N₄OS · xH₂O
• Peso molecolare: 374.46 (anhydrous basis)
• Numero MDL: MFCD21363374
• Codice UNSPSC: 51111800
• ID PubChem: 329823762
• NACRES: NA.77

Proprietà

• Saggio: ≥98% (HPLC)
• Stato: powder
• Colore: yellow to orange
• Solubilità: DMSO: ≥15 mg/mL
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: O.C[C@@H]1CNc2c(sc3ccc4nc(ccc4c23)-c5ccc(C)nc5)C(=O)N1
• InChI: 1S/C21H18N4OS.H2O/c1-11-3-4-13(10-22-11)15-6-5-14-16(25-15)7-8-17-18(14)19-20(27-17)21(26)24-12(2)9-23-19;/h3-8,10,12,23H,9H2,1-2H3,(H,24,26);1H2/t12-;/m1./s1; WHVUIWUUCVXAGR-UTONKHPSSA-N

Descrizione

Applicazioni

PF-3644022 hydrate has been used for the inhibition of mitogen-activated protein kinase 2 (MK2) in human osteosarcoma cells (U2OS)[1] and in colorectal carcinoma cells (CT26).[2]

Azioni biochim/fisiol

PF-3644022 hydrate is a MK2 inhibitor

PF-3644022 is a potent inhibitor of mitogen-activated protein kinase-activated protein kinase 2 (MK2; Ki = 3 nM). PF-3644022 inhibits TNFa and IL-6 production in LPS-stimulated human whole blood (IC₅₀ = 1.6 and 10.3 μM, respectively) and blocks TNFα production and paw swelling in a streptococcal cell wall-induced arthritis in rats.

Caratteristiche e vantaggi

This compound is featured on the MAPKAPs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Altre note

PF3644022 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the PF3644022 probe summary on the Chemical Probes Portal website.

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H302,H319
• Consigli di prudenza: P264 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313 - P501
• Classi di pericolo: Acute Tox. 4 Oral - Eye Irrit. 2
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable