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P0022

Sigma-Aldrich

PS48

≥98% (HPLC)

Sinonimo/i:

5-(4-Chloro-phenyl)-3-phenyl-pent-2-enoic acid

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About This Item

Formula empirica (notazione di Hill):
C17H15ClO2
Numero CAS:
1180676-32-7
Peso molecolare:
286.75
Numero MDL:
MFCD17215962
Codice UNSPSC:
12352200
ID PubChem:
329819977
NACRES:
NA.77

Saggio

≥98% (HPLC)

Stato

powder

Condizioni di stoccaggio

protect from light

Colore

white to off-white

Solubilità

DMSO: >20 mg/mL

Temperatura di conservazione

2-8°C

Stringa SMILE

OC(=O)\C=C(\CCc1ccc(Cl)cc1)c2ccccc2

InChI

1S/C17H15ClO2/c18-16-10-7-13(8-11-16)6-9-15(12-17(19)20)14-4-2-1-3-5-14/h1-5,7-8,10-12H,6,9H2,(H,19,20)/b15-12-
LLJYFDRQFPQGNY-QINSGFPZSA-N

Azioni biochim/fisiol

PDK1 (phosphoinositide-dependent protein kinase 1) activator which binds to the HM/PIF binding pocket rather than the ATP-binding site.
PS48 is a PDK1 (phosphoinositide-dependent protein kinase 1) activator which binds to the HM/PIF binding pocket rather than the ATP-binding site. PS48 is one of only a few truly allosteric compounds targeting a regulatory binding site on a protein kinase catalytic domain that is not adjacent to or overlapping with the ATP-binding site.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number
0000288009
0000288009
0000353883
025M4705V

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