O4139

Orlistat

≥98% (HPLC), solid, lipase inhibitor

• Sinonimo/i: (−)-Tetrahydrolipstatin, N-Formyl-L-leucine (1S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester, Ro-18-0647
• Formula empirica (notazione di Hill): C₂₉H₅₃NO₅
• Numero CAS: 96829-58-2
• Peso molecolare: 495.73
• Numero MDL: MFCD05662360
• Codice UNSPSC: 41106300
• ID PubChem: 24724564
• NACRES: NA.77

Proprietà

• product name: Orlistat, ≥98%, solid
• Origine biologica: synthetic (organic)
• Livello qualitativo: 200
• Saggio: ≥98%
• Forma fisica: solid
• Colore: white
• Punto di fusione: <50 °C
• Solubilità: DMSO: 19 mg/mL
• Ideatore: Roche
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@H](CC(C)C)NC=O
• InChI: 1S/C29H53NO5/c1-5-7-9-11-12-13-14-15-16-18-24(34-29(33)26(30-22-31)20-23(3)4)21-27-25(28(32)35-27)19-17-10-8-6-2/h22-27H,5-21H2,1-4H3,(H,30,31)/t24-,25-,26-,27-/m0/s1; AHLBNYSZXLDEJQ-FWEHEUNISA-N
• Informazioni sul gene: human ... LIPF(8513) , PNLIP(5406)

Descrizione

Descrizione generale

Orlistat acts as a gastric lipase inhibitor that reduces fat absorption.

Applicazioni

Orlistat has been used as an inhibitor:

• of fatty acid synthase in long-term estrogen-deprived (LTED) variant cell lines
• of lipase in screening lipase inhibition by raspberry extract
• in in vitro pancreatic lipase activity assay

Azioni biochim/fisiol

Orlistat impairs intestinal fat absorption and is effective in weight management. It is regarded as a safe drug for treating obesity. It delays the progression of type 2 diabetes mellitus especially in obese and improves glycemic parameters. Long term usage of orlistat results in improved weight reduction and it may not contribute in colorectal carcinogenesis.

Orlistat, used in obesity research, is a pancreatic lipase inhibitor that acts locally in the gastrointestinal tract to inhibit lipase.

Caratteristiche e vantaggi

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Altre note

Solution is not completely clear, small particles may remain floating.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)