MAK105
Phosphoglucomutase Colorimetric Assay Kit
sufficient for 100 colorimetric tests
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About This Item
Codice UNSPSC:
12352200
NACRES:
NA.84
Prodotti consigliati
impiego
sufficient for 100 colorimetric tests
Metodo di rivelazione
colorimetric
Temperatura di conservazione
−20°C
Descrizione generale
Phosphoglucomutase (PGM) is an enzyme crucial for the interconversion of glucose-1-phosphate and glucose-6-phosphate. In glycogenolysis, PGM converts glucose-1-phosphate into glucose-6-phosphate for use in either the glycolytic pathway or pentose phosphate pathway. When blood glucose levels are high, PGM will convert excess glucose-6-phosphate (formed from glucose by the action of hexokinase) to glucose-1-phosphate.
Deficiency of phosphoglucomutase leads to glycogen storage disease.
Deficiency of phosphoglucomutase leads to glycogen storage disease.
Compatibilità
Suitable for the measurement of phosphoglucomutase activity, analysis of glucose metabolism and cell signaling and screening anti-diabetic drugs in animal tissues (muscle, liver, heart, kidney etc.), cell culture (adherent or suspension cells) and plasma.
Principio
The Phosphoglucomutase Colorimetric Assay kit provides a simple and direct procedure for measuring PGM activity in a variety of samples. PGM activity is determined by a coupled enzyme assay in which glucose-1-phosphate is converted by PGM to glucose-6-phosphate. Glucose-6-phosphate is subsequently oxidized to form a product, which reacts with a probe generating a colorimetric (450 nm) product proportional to the PGM activity present. One unit of PGM is the amount of enzyme that will generate 1.0 μmole of NADH per minute at pH 8.0 at room temperature.
Avvertenze
Danger
Indicazioni di pericolo
Consigli di prudenza
Classi di pericolo
Resp. Sens. 1
Codice della classe di stoccaggio
10 - Combustible liquids
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Feher J J
Quantitative Human Physiology, 1008-1008 (2017)
Phosphoglucomutase (PGM 1) deficiency: a novel defect of muscle glycogen degradation and synthesis (P07. 200).
Haller R, et al.
Neurology, 78(1), P07-200 (2012)
The enzyme phosphoglucomutase (Pgm) is required by Salmonella enterica serovar Typhimurium for O-antigen production, resistance to antimicrobial peptides and in vivo fitness.
Paterson G K< et al.
Microbiology, 155(10), 3403-3410 (2009)
Liver glucose metabolism in humans.
Adeva-Andany M M, et al.
Bioscience Reports, BSR20160385-BSR20160385 (2016)
Jessica N R Peoples et al.
The Journal of biological chemistry, 293(18), 6925-6941 (2018-03-16)
Cardiac energy demands during early embryonic periods are sufficiently met through glycolysis, but as development proceeds, the oxidative phosphorylation in mitochondria becomes increasingly vital. Adrenergic hormones are known to stimulate metabolism in adult mammals and are essential for embryonic development
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