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Merck
Tutte le immagini(1)

Documenti

M8631

Sigma-Aldrich

Melanin

Synthetic

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About This Item

Numero CAS:
8049-97-6
Numero CE:
232-473-6
Numero MDL:
MFCD00131581
Codice UNSPSC:
12352204
NACRES:
NA.83

Livello qualitativo

100

Forma fisica

powder

Temperatura di conservazione

−20°C

InChI

1S/C18H10N2O4/c1-5-13-9-7(3-19-13)12-10-8(11(9)17(23)15(5)21)4-20-14(10)6(2)16(22)18(12)24/h3-4,19-20H,1-2H3
XUMBMVFBXHLACL-UHFFFAOYSA-N

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Descrizione generale

Melanin is a vital pigment present on the surface structures of vertebrates, which contribute to skin color. It has three forms such as, eumelanin, pheomelanin and neuromelanin. Melanin has cation chelating and redox properties. It is a potent absorbent of light. Melanin functions as a chemoprotective and photoprotective pigment. Mutations in this gene are associated with oculocutaneous albinism, vitiligo, piebaldism and Waardenburg syndrome.

Applicazioni

Melanin has been used:
  • in spectrophotometry
  • to study its effect on reverse transcription polymerase chain reaction (RT-PCR) inhibition and effect of BSA (bovine serum albumin) in overcoming the inhibition
  • as an absorber for skin layer in near-infrared tissue spectra
  • Raman spectroscopy

Nota sulla preparazione

Prepared by oxidation of tyrosine with hydrogen peroxide.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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Pyroquilon PESTANAL®, analytical standard

Supelco

45650

Pyroquilon

Tirosinasi lyophilized powder, ≥1000 unit/mg solid

Sigma-Aldrich

T3824

Tirosinasi

1,8-Dihydroxynaphthalene 95%

Sigma-Aldrich

740683

1,8-Dihydroxynaphthalene

Terrein from Aspergillus terreus, ≥98% (HPLC)

Sigma-Aldrich

T5705

Terrein

Bovine serum albumin reverses inhibition of RT-PCR by melanin
Giambernardi TA, et al.
Biotechniques, 25(4), 564-566 (1998)
Melanin
Riley PA
The International Journal of Biochemistry & Cell Biology, 29(11), 1235-1239 (1997)
Constant rate of steady-state self-antigen trafficking from skin to regional lymph nodes
Yoshino M, et al.
International Immunology, 18(11), 1541-1548 (2006)
Justyna M Drewnowska et al.
PloS one, 10(4), e0125428-e0125428 (2015-04-25)
Although melanin is known for protecting living organisms from harmful physical and chemical factors, its synthesis is rarely observed among endospore-forming Bacillus cereus sensu lato. Here, for the first time, we reported that psychrotolerant Bacillus weihenstephanensis from Northeastern Poland can
Zheng Wang et al.
Frontiers in microbiology, 4, 379-379 (2014-01-01)
Melanization due to the inactivation of the homogentisate-1,2-dioxygenase gene (hmgA) has been demonstrated to increase stress resistance, persistence, and virulence in some bacterial species but such pigmented mutants have not been observed in pathogenic members of the Vibrio Harveyi clade.
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