I3159
IMD-0354
≥98% (HPLC), solid
Sinonimo/i:
N-(3,5-Bis-trifluoromethylphenyl)-5-chloro-2-hydroxybenzamide
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| A voi/SKU | Disponibilità | Prezzo |
|---|---|---|
5 mg | Per informazioni sulla disponibilità, contatta il Servizio Clienti. | 279,00 € |
10 mg | Per informazioni sulla disponibilità, contatta il Servizio Clienti. | 411,00 € |
Informazioni su questo articolo
Formula empirica (notazione di Hill):
C15H8ClF6NO2
Numero CAS:
Peso molecolare:
383.67
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
279,00 €
Per informazioni sulla disponibilità, contatta il Servizio Clienti.
Servizio Tecnico
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Permettici di aiutartiassay
≥98% (HPLC)
form
solid
solubility
DMSO: >20 mg/mL
shipped in
wet ice
storage temp.
−20°C
SMILES string
Oc1ccc(Cl)cc1C(=O)Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F
InChI
1S/C15H8ClF6NO2/c16-9-1-2-12(24)11(6-9)13(25)23-10-4-7(14(17,18)19)3-8(5-10)15(20,21)22/h1-6,24H,(H,23,25)
InChI key
CHILCFMQWMQVAL-UHFFFAOYSA-N
Application
IMD-0354 has been used to study the effect of NF-κB (nuclear factor) inhibition on differentially expressed in chondrocytes 2. It has also been used to study the role of NF-κB signaling in tumor necrosis factor-induced certain transcription factors expression using human primary fibroblasts.
Biochem/physiol Actions
IMD-0354 acts as an inhibitor by inhibiting the phosphorylation of the NF-κB (nuclear factor) and its translocation into the nucleus. It blocks IκBα phosphorylation (IC50 ~ 250 nM). Cardioprotectant, that reduces IL-1β and MCP-1 production (IC50 < 1 μM) in cardiomyocytes. IMD-0354 affects angiogenesis, which has been observed in human umbilical vein endothelial cells. It prevents tube formation and migration of the cells. In vivo studies also prove that IMD-0354 inhibits retinal vessel growth. IMD-0354 also acts as an inhibitor of Aquaporin 4 (AQP4) inhibitor (IC50 0.2μM) with no inhibitory potency to IKK-β. [4]
Packaging
Light sensitive. Packaged under nitrogen.
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Questo articolo | |||
|---|---|---|---|
| form solid | form powder | form solid | form powder |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. −20°C | storage temp. room temp | storage temp. - | storage temp. −20°C |
| solubility DMSO: >20 mg/mL | solubility DMSO: 20 mg/mL, clear | solubility H2O: 10 mg/mL | solubility DMSO: 20 mg/mL, clear |
| shipped in wet ice | shipped in - | shipped in - | shipped in - |
Classe di stoccaggio
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
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