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Merck
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Documenti

H9414

Sigma-Aldrich

Halofantrine

≥98% (HPLC), solid

Sinonimo/i:

1,3-Dichloro-a-[2-(dibutylamino)ethyl]-6-(trifluoromethyl)-9-phenanthrenemethanol, Halfan

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About This Item

Formula empirica (notazione di Hill):
C26H30Cl2F3NO · HCl
Numero CAS:
36167-63-2
Peso molecolare:
536.88
Numero CE:
252-895-4
Numero MDL:
MFCD00879136
Codice UNSPSC:
12352200
ID PubChem:
329815264
NACRES:
NA.77

Saggio

≥98% (HPLC)

Forma fisica

solid

Condizioni di stoccaggio

desiccated

Colore

white to off-white

Solubilità

DMSO: >10 mg/mL

Ideatore

GlaxoSmithKline

Temperatura di conservazione

2-8°C

Stringa SMILE

Cl.CCCCN(CCCC)CCC(O)c1cc2c(Cl)cc(Cl)cc2c3cc(ccc13)C(F)(F)F

InChI

1S/C26H30Cl2F3NO.ClH/c1-3-5-10-32(11-6-4-2)12-9-25(33)23-16-22-21(14-18(27)15-24(22)28)20-13-17(26(29,30)31)7-8-19(20)23;/h7-8,13-16,25,33H,3-6,9-12H2,1-2H3;1H
WANGFTDWOFGECH-UHFFFAOYSA-N

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Azioni biochim/fisiol

Halofantrine is a blocker of delayed rectifier potassium current via the inhibition of hERG channel.

Caratteristiche e vantaggi

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Indicazioni di pericolo

H413

Consigli di prudenza

P273 - P501

Classi di pericolo

Aquatic Chronic 4

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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René Holm et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 81(2), 281-287 (2012-04-03)
The bioavailability of the poorly soluble model drug halofantrine, dosed in a soy bean oil solution or in a self-nanoemulsifying drug delivery system (SNEDDS), at two levels of lipid, was assessed in rats. Three rat models were used: intact rats
Martin Traebert et al.
European journal of pharmacology, 484(1), 41-48 (2004-01-20)
Several antimalarial drugs are known to produce a QT interval prolongation via a blockade of the rapidly activating delayed rectifier K+ current (IKr), encoded by the human-ether-a-go-go-related gene (hERG). We investigated the influence of lumefantrine and its major metabolite desbutyl-lumefantrine
Jigar P Patel et al.
Chirality, 24(7), 558-565 (2012-05-17)
Experimental hyperlipidemia has shown to decrease cytochrome P450 3A4 and 2C11 expression and to increase liver concentrations and the plasma protein binding of halofantrine (HF) enantiomers. The present study examined the effect of hyperlipidemic (HL) serum on the metabolism of
Kerenaftali Klein et al.
The Journal of pharmacy and pharmacology, 64(11), 1603-1613 (2012-10-13)
To investigate the population pharmacokinetics of the antimalarial halofantrine (HF) in healthy volunteers and patients with symptomatic falciparum malaria. Healthy volunteer data were obtained from six volunteers who received three different doses of HF (250, 500 and 1000 mg) after
Daria Van Tyne et al.
PLoS genetics, 7(4), e1001383-e1001383 (2011-05-03)
The Plasmodium falciparum parasite's ability to adapt to environmental pressures, such as the human immune system and antimalarial drugs, makes malaria an enduring burden to public health. Understanding the genetic basis of these adaptations is critical to intervening successfully against
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