H1771

3-Hydroxy-DL-kynurenine

• Sinonimo/i: α,2-Diamino-3-hydroxy-γ-oxobenzenebutanoic acid
• Formula empirica (notazione di Hill): C₁₀H₁₂N₂O₄
• Numero CAS: 484-78-6
• Peso molecolare: 224.21
• Numero MDL: MFCD00047832
• Codice UNSPSC: 12352204
• ID PubChem: 24895482
• NACRES: NA.32

Proprietà

• Saggio: ≥98% (TLC)
• Livello qualitativo: 200
• Forma fisica: powder
• Solubilità: 1 M HCl: 49.00-51.00 mg/mL, clear to very slightly hazy
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: NC(CC(=O)c1cccc(O)c1N)C(O)=O
• InChI: 1S/C10H12N2O4/c11-6(10(15)16)4-8(14)5-2-1-3-7(13)9(5)12/h1-3,6,13H,4,11-12H2,(H,15,16); VCKPUUFAIGNJHC-UHFFFAOYSA-N

Descrizione

Descrizione generale

3-Hydroxy-DL-kynurenine is a tryptophan metabolite with a molecular weight corresponding to 224Da. It is a chromophore or hydrophilic yellow compound present in the lens of the eye. 3-Hydroxy-DL-kynurenine is synthesized from kynurenine by the action of enzyme kynurenine 3-monooxygenase (KMO). It is metabolized to 3-hydroxyanthranilic acid and xanthurenic acid in the presence of enzymes kynureninase and kynurenine aminotransferases, respectively.

Applicazioni

3-Hydroxy-DL-kynurenine has been used:

• as a substrate for the recombinant human kynureninase assay
• as a reference standard in tandem mass spectrometry (MS/MS) analysis
• as a control for quantifying serum 3-Hydroxy-DL-kynurenine levels in diabetic retinopathy patients

Azioni biochim/fisiol

3-Hydroxy-DL-kynurenine (3-HKYN) has antioxidant functionality and prevents lipid peroxidation in cerebral cortex. It may modulate synaptic neurotransmission. The levels of 3-HKYN is elevated in Huntington′s disease. However, its role in neurodegenerative diseases is still not understood well. Kynurenine metabolism is linked with glutamatergic neurotransmission and the level of 3-HKYN is linked to the pathophysiology of schizophrenia.

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H315,H319,H335
• Consigli di prudenza: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Classi di pericolo: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organi bersaglio: Respiratory system
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Gloves