D048

MPP⁺ iodide

≥98% (HPLC), powder

• Sinonimo/i: 1-Methyl-4-phenylpyridinium iodide
• Formula empirica (notazione di Hill): C₁₂H₁₂IN
• Numero CAS: 36913-39-0
• Peso molecolare: 297.13
• Numero MDL: MFCD00055096
• Codice UNSPSC: 12352200
• ID PubChem: 24893235
• NACRES: NA.77

Proprietà

• Saggio: ≥98% (HPLC)
• Stato: powder
• Condizioni di stoccaggio: desiccated
• Colore: white to beige
• Solubilità: H₂O: 10 mg/mL, clear
• Stringa SMILE: [I-].C[n+]1ccc(cc1)-c2ccccc2
• InChI: 1S/C12H12N.HI/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11;/h2-10H,1H3;1H/q+1;/p-1; RFDFRDXIIKROAI-UHFFFAOYSA-M

Descrizione

Descrizione generale

1-Methyl-4-phenylpyridinium (MPP+) acts as a selective ERα antagonist.[1]induces neurotoxicity by inhibiting mitochondrial redox functions in the striatal synaptosomes.[2] It is a potential neurotoxin and induces Parkinson′s disease in animal models. It mediates apoptosis by the generation of reactive oxygen species in cerebellar granule neurons and neuroblastoma cells.[3] MPP+ modulates the distribution of dopamine.[4] It elicits neurotoxicity by activating neuronal nitric oxide synthase (nNOS), resulting in excess nitric oxide.[5]

Applicazioni

MPP+ iodide has been used:

• to induce oxidative stress in zebrafish embryos[6]
• for the inhibition of glutamate uptake in mitochondria of astrocytes[7]
• in testing cell viability using MTT (3 (4,5-dimethylthiazol)-2-yl-2,5-diphenyltetrazolium bromide) in microglia (BV2) cells[8]

Azioni biochim/fisiol

Active metabolite of dopaminergic neurotoxin MPTP

MPP⁺ iodide is an active metabolite of dopaminergic neurotoxin MPTP.

Avvertenza

Photosensitive.

Nota sulla preparazione

Solutions should be freshly prepared.

Altre note

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Informazioni sulla sicurezza

• Pittogrammi: GHS06
• Avvertenze: Danger
• Indicazioni di pericolo: H301 + H311 + H331,H315,H319,H335
• Consigli di prudenza: P261 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P311 - P305 + P351 + P338
• Classi di pericolo: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organi bersaglio: Respiratory system
• Codice della classe di stoccaggio: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges