C3138
Cathepsin D from bovine spleen
lyophilized powder, ≥2.0 units/mg protein
Sinonimo/i:
CTSD
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5 UNITS
244,00 €
10 UNITS
418,00 €
20 UNITS
829,00 €
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Cambia visualizzazione
5 UNITS
244,00 €
10 UNITS
418,00 €
20 UNITS
829,00 €
About This Item
Numero CAS:
Numero MDL:
Codice UNSPSC:
12352204
NACRES:
NA.32
Prodotti consigliati
Origine biologica
bovine spleen
Saggio
10—70% protein (biuret)
Stato
lyophilized powder
Attività specifica
≥2.0 units/mg protein
PM
~45 kDa
Produttore/marchio commerciale
Sigma-Aldrich
tecniche
activity assay: suitable
Colore
dark brown
Compatibilità
suitable for molecular biology
N° accesso UniProt
applicazioni
life science and biopharma
Temperatura di conservazione
−20°C
Informazioni sul gene
cow ... CTSD(282883)
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Descrizione generale
Applicazioni
Cathepsin D from bovine spleen has been used:
- in in vitro dose-dependent fluorometric activity assays.[3]
- in in vitro myelin oligodendrocyte glycoprotein (MOG) digestion to study the uptake of malondialdehyde (MDA)-modified MOG and its implications in central nervous system autoimmunity.[4]
- for enzymatic digestion of the proteoglycan moiety of the articular cartilage in order to determine its dynamic elastic modulus at two different levels of tissue organization.[5]
- in cathepsin D activity assay.[6]
Azioni biochim/fisiol
Cathepsin D is an endosomal-lysosomal aspartic protease implicated in breast cancer metastasis and Alzheimer′s disease. Lysosomal release of cathepsin D has been found to precede cytochrome c release and loss of membrane potential in apoptotic human foreskin fibroblasts. Cathepsin D levels in PC12 cells increase 12 to 24 hours after apoptosis is induced.
Endosomal-lysosomal aspartic protease implicated in breast cancer metastasis and Alzheimer′s disease. Lysosomal release of cathepsin D has been found to precede cytochrome c release and loss of membrane potential in apoptotic human foreskin fibroblasts.
Definizione di unità
One unit will produce an increase in A280 of 1.0 per min per mL at pH 3.0 at 37 °C measured as TCA-soluble products using hemoglobin as substrate (1 cm light path).
Stato fisico
Lyophilized powder containing citrate buffer salts
Inibitore
N° Catalogo
Descrizione
Determinazione del prezzo
Prodotti correlati
N° Catalogo
Descrizione
Determinazione del prezzo
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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I clienti hanno visto anche
Martin Stolz et al.
Biophysical journal, 86(5), 3269-3283 (2004-04-28)
Cartilage stiffness was measured ex vivo at the micrometer and nanometer scales to explore structure-mechanical property relationships at smaller scales than has been done previously. A method was developed to measure the dynamic elastic modulus, |E(*)|, in compression by indentation-type
Olja Mijanovic et al.
Pharmaceutics, 13(6) (2021-07-03)
Lysosomal proteases play a crucial role in maintaining cell homeostasis. Human cathepsin D manages protein turnover degrading misfolded and aggregated proteins and favors apoptosis in the case of proteostasis disruption. However, when cathepsin D regulation is affected, it can contribute
Jason S King et al.
Molecular biology of the cell, 24(17), 2714-2726 (2013-07-26)
Wiskott-Aldrich syndrome protein and SCAR homologue (WASH) is an important regulator of vesicle trafficking. By generating actin on the surface of intracellular vesicles, WASH is able to directly regulate endosomal sorting and maturation. We report that, in Dictyostelium, WASH is
Cathepsin D from porcine and bovine spleen.
T Takahashi et al.
Methods in enzymology, 80 Pt C, 565-581 (1981-01-01)
Yoko Shiba et al.
Current biology : CB, 23(19), 1945-1951 (2013-10-01)
ArfGAPs are known to be involved in cargo sorting in COPI transport. However, the role of ArfGAPs in post-Golgi membrane traffic has not been defined. To determine the function of ArfGAPs in post-Golgi traffic, we used small interfering RNA to
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