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B154

BU224 hydrochloride

solid

Sinonimo/i:

2-(4,5-Dihydroimidazol-2-yl)quinoline hydrochloride

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Informazioni su questo articolo

Formula empirica (notazione di Hill):
C12H11N3 · HCl
Peso molecolare:
233.70
NACRES:
NA.77
PubChem Substance ID:
24277761
UNSPSC Code:
12352202
MDL number:
MFCD00467639
Form:
solid
Quality level:
200
Prezzi e disponibilità al momento non sono disponibili
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form

solid

Quality Level

200

color

white

solubility

ethanol: 1.2 mg/mL, H2O: >16 mg/mL, 0.1 M NaOH: 24 mg/mL, 0.1 M HCl: >30 mg/mL

SMILES string

Cl[H].C1CN=C(N1)c2ccc3ccccc3n2

InChI

1S/C12H11N3.ClH/c1-2-4-10-9(3-1)5-6-11(15-10)12-13-7-8-14-12;/h1-6H,7-8H2,(H,13,14);1H

InChI key

DDFHQXAQWZWRSQ-UHFFFAOYSA-N

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Questo articolo
C8417B4311Z101
BU224 hydrochloride solid

Sigma-Aldrich

B154

BU224 hydrochloride

N-(2-Chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride ≥98%, solid

Sigma-Aldrich

C8417

N-(2-Chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride

BF-170 hydrochloride ≥98% (HPLC), solid

Sigma-Aldrich

B4311

BF-170 hydrochloride

Zimelidine dihydrochloride solid

Sigma-Aldrich

Z101

Zimelidine dihydrochloride

form

solid

form

solid

form

solid

form

solid

Quality Level

200

Quality Level

200

Quality Level

100

Quality Level

100

solubility

ethanol: 1.2 mg/mL, 0.1 M NaOH: 24 mg/mL, H2O: >16 mg/mL

solubility

H2O: 48 mg/mL, 0.1 M NaOH: 7 mg/mL, ethanol: soluble

solubility

H2O: 10 mg/mL

solubility

0.1 M HCl: 45 mg/mL, H2O: 66 mg/mL

color

white

color

white

color

orange

color

white

Biochem/physiol Actions

I2 Imidazoline receptor antagonist.

Features and Benefits

This compound is featured on the Imidazoline Binding Sites page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Disclaimer

Hygroscopic; store desiccated

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Classe di stoccaggio

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Lot/Batch Number

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A Diaz et al.
European journal of pharmacology, 333(1), 9-15 (1997-08-20)
In this electrophysiological study, the effect of BU-224 (2-(4,5-dihydroimidazol-2yl)-quinoline hydrochloride)), a novel high affinity imidazoline I2 receptor ligand, was tested on the responses of nociceptive neurones in the spinal dorsal horn. When applied spinally, akin to an intrathecal application (i.t.)
A L Hudson et al.
Annals of the New York Academy of Sciences, 881, 81-91 (1999-07-23)
Over several years our group has sought to synthesize and identify selective ligands for imidazoline (I) receptors, in particular the I2 binding site. As a consequence, [3H]2-(2-benzofuranyl)-2-imidazoline (2BFI) has proved extremely useful for binding and autoradiographic studies. More recently we
Laura Micheli et al.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 17(3), 1005-1015 (2020-06-24)
Anti-cancer therapy based on the repeated administration of oxaliplatin is limited by the development of a disabling neuropathic syndrome with detrimental effects on the patient's quality of life. The lack of effective pharmacological approaches calls for the identification of innovative
Nazanin Mirzaei et al.
British journal of pharmacology, 178(3), 654-671 (2020-11-04)
Activation of type 2 imidazoline receptors has been shown to exhibit neuroprotective properties including anti-apoptotic and anti-inflammatory effects, suggesting a potential therapeutic value in Alzheimer's disease (AD). Here, we explored the effects of the imidazoline-2 ligand BU224 in a model
Kazunori Kawamura et al.
Nuclear medicine and biology, 45, 1-7 (2016-11-12)
A positron emission tomography (PET) probe with ultra-high specific radioactivity (SA) enables measuring high receptor specific binding in brain regions by avoiding mass effect of the PET probe itself. It has been reported that PET probe with ultra-high SA can
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Numero articolo commerciale globale

SKUGTIN
B154-5MG04061832088808

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