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AV47141

Sigma-Aldrich

Anti-ZDHHC17 (AB1) antibody produced in rabbit

affinity isolated antibody

Sinonimo/i:

Anti-HIP14, Anti-HIP3, Anti-HSPC294, Anti-HYPH, Anti-KIAA0946, Anti-Zinc finger, DHHC-type containing 17

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About This Item

Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

rabbit

Livello qualitativo

100

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

buffered aqueous solution

PM

73 kDa

Reattività contro le specie

rat, human, mouse, bovine, guinea pig, horse, rabbit, dog

Concentrazione

0.5 mg - 1 mg/mL

tecniche

immunohistochemistry: suitable
western blot: suitable

N° accesso NCBI

NP_056151

N° accesso UniProt

Q8IUH5

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... ZDHHC17(23390)

Immunogeno

Synthetic peptide directed towards the middle region of human ZDHHC17

Applicazioni

Anti-ZDHHC17 (AB1) antibody produced in rabbit is suitable for western blotting at a concentration of 1μg/mL.

Azioni biochim/fisiol

ZDHHC17 is a palmitoyl acyl transferase (PAT) expressed primarily in insulin-positive cells in islets of Langerhans. Overexpression of HIP14 is related to a reduction in IL-1beta-induced NF-kappaB activity and it can also protect against IL-1beta-mediated apoptosis. Additionally, it is a ClipR-59 palmitoyltransferase that modifies the ClipR-59 plasma membrane binding and hence regulates the Akt signaling as well as Glut4 membrane translocation in adipocytes. It also facilitates the Mg2+ transport.

Sequenza

Synthetic peptide located within the following region: LFYNFGKSWKSDPGIIKATEEQKKKTIVELAETGSLDLSIFCSTCLIRKP

Stato fisico

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Angela Goytain et al.
The Journal of biological chemistry, 283(48), 33365-33374 (2008-09-17)
Polyglutamine expansions of huntingtin protein are responsible for the Huntington neurological disorder. HIP14 protein has been shown to interact with huntingtin. HIP14 and a HIP14-like protein, HIP14L, with a 69% similarity reside in the Golgi and possess palmitoyl acyltransferase activity
Lukas Adrian Berchtold et al.
Proceedings of the National Academy of Sciences of the United States of America, 108(37), E681-E688 (2011-06-28)
Type 1 diabetes (T1D) is a complex disease characterized by the loss of insulin-secreting β-cells. Although the disease has a strong genetic component, and several loci are known to increase T1D susceptibility risk, only few causal genes have currently been
Wenying Ren et al.
Molecular and cellular biology, 33(21), 4255-4265 (2013-09-05)
ClipR-59 interacts with Akt and regulates Akt compartmentalization and Glut4 membrane trafficking in a plasma membrane association-dependent manner. The association of ClipR-59 with plasma membrane is mediated by ClipR-59 palmitoylation at Cys534 and Cys535. To understand the regulation of ClipR-59
Activity-dependent post-translational regulation of palmitoylating and depalmitoylating enzymes in the hippocampus.
Abazari, et al.
Journal of Cell Science, 136 (2023)

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