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A5855

Sigma-Aldrich

Abz-LFK(Dnp)-OH

≥97% (HPLC)

Sinonimo/i:

O-Aminobenzoic acid-Leu-Phe-Lys(DNP)-OH

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About This Item

Formula empirica (notazione di Hill):
C34H41N7O9 · xC2HF3O2
Peso molecolare:
691.73 (free base basis)
Numero MDL:
MFCD11045275
Codice UNSPSC:
12352200
ID PubChem:
329770877
NACRES:
NA.77

Saggio

≥97% (HPLC)

Forma fisica

film

Colore

yellow

Temperatura di conservazione

2-8°C

Stringa SMILE

OC(=O)C(F)(F)F.CC(C)C[C@H](NC(=O)c1ccccc1N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCCNc3ccc(cc3[N+]([O-])=O)[N+]([O-])=O)C(O)=O

InChI

1S/C34H41N7O9.C2HF3O2/c1-21(2)18-28(38-31(42)24-12-6-7-13-25(24)35)32(43)39-29(19-22-10-4-3-5-11-22)33(44)37-27(34(45)46)14-8-9-17-36-26-16-15-23(40(47)48)20-30(26)41(49)50;3-2(4,5)1(6)7/h3-7,10-13,15-16,20-21,27-29,36H,8-9,14,17-19,35H2,1-2H3,(H,37,44)(H,38,42)(H,39,43)(H,45,46);(H,6,7)/t27-,28-,29-;/m0./s1
BAXBDLHYKKDHEJ-BJRQXHFHSA-N

Amino Acid Sequence

Abz-Leu-Phe-Lys-DNP

Applicazioni

Abz-LFK(Dnp)-OH trifluoroacetate (TFA) salt is an Angiotensin Converting Enzyme (ACE) fluorescent peptide substrate that binds specifically to the C domain of ACE. Abz-LFK(Dnp)-OH TFA has been used to study the development of new antibacterial calixarene derivatives, as well as the efficacy and toxicity of the antimicrobial peptide M33 as a possible antimicrobial agent in lung infections and sepsis.

Azioni biochim/fisiol

Abz-LFK(Dnp)-OH is an Angiotensin Converting Enzyme (ACE) fluorescent peptide substrate specific for the C domain for real time fluorescent assay (ACE, Peptidyl Dipeptidase, Kininase II, E.C. 3.4.15.1).

Caratteristiche e vantaggi

This compound is featured on the Angiotensin Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

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Guillaume Sautrey et al.
The journal of physical chemistry. B, 115(50), 15002-15012 (2011-11-16)
Tetra-p-guanidinoethylcalix[4]arene trifluoroacetate salt (CX1) was synthesized recently as an antibacterial agent. It showed to be active in vitro against various Gram-positive and Gram-negative bacteria. To get more insight in the mechanism of the biological activity of this derivative, it was
L-arginine trifluoroacetate salt bridges in its solid state compound: the low-temperature three dimensional structural determination of L-arginine bis(trifluoroacetate) crystal and its vibrational spectral analysis
Sun, Z.H., et al.
Spectrochimica Acta Part A: Molecular Spectroscopy, 83, 39-45 (2011)
Alessandro Pini et al.
Amino acids, 43(1), 467-473 (2011-10-11)
The tetra-branched peptide M33 (Pini et al. in FASEB J 24:1015-1022, 2010) is under evaluation in animal models for its activity as antimicrobial agent in lung infections and sepsis. The preclinical development of a new drug requires medium-scale manufacture for

Articoli

Angiotensin Receptors

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