A4308

Autocamtide 2-related inhibitory peptide

≥97% (HPLC), lyophilized powder

• Sinonimo/i: [Ala⁹]-Autocamtide 2, AIP
• Formula empirica (notazione di Hill): C₆₄H₁₁₆N₂₂O₁₉
• Numero CAS: 167114-91-2
• Peso molecolare: 1497.74
• Codice UNSPSC: 12352202
• ID PubChem: 329770854
• NACRES: NA.77

Proprietà

• Origine biologica: synthetic
• Saggio: ≥97% (HPLC)
• Stato: lyophilized powder
• PM: ~_1.5 kDa
• Composizione: Peptide content, ≥70%
• Solubilità: H₂O: soluble
• Temperatura di conservazione: −20°C
• Stringa SMILE: CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](CC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)CC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(C)C)C(O)=O
• InChI: 1S/C65H114N20O21/c1-32(2)28-46(63(105)106)85-54(96)36(7)78-62(104)45(31-52(93)94)84-56(98)38(33(3)4)30-47(86)34(5)76-59(101)43(19-22-50(89)90)81-55(97)37(18-21-49(69)88)29-48(87)40(16-12-26-74-64(70)71)79-60(102)42(17-13-27-75-65(72)73)83-61(103)44(20-23-51(91)92)80-53(95)35(6)77-58(100)41(15-9-11-25-67)82-57(99)39(68)14-8-10-24-66/h32-46H,8-31,66-68H2,1-7H3,(H2,69,88)(H,76,101)(H,77,100)(H,78,104)(H,79,102)(H,80,95)(H,81,97)(H,82,99)(H,83,103)(H,84,98)(H,85,96)(H,89,90)(H,91,92)(H,93,94)(H,105,106)(H4,70,71,74)(H4,72,73,75)/t34-,35-,36-,37+,38-,39-,40-,41-,42-,43-,44-,45-,46-/m0/s1; COEHZSYVSXUBHI-CYZNULJVSA-N
• Informazioni sul gene: human ... CAMK2A(815) , CAMK2B(816) , CAMK2D(817) ; mouse ... CAMK2A(12322) , CAMK2B(12323) , CAMK2D(108058) ; rat ... CAMK2A(25400) , CAMK2B(24245) , CAMK2D(24246)

Descrizione

Amino Acid Sequence

Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Ala-Val-Asp-Ala-Leu

Applicazioni

Autocamtide 2-related inhibitory peptide has been used:

• To inhibit calmodulin kinase II (CaMKII) action in virulent Theileria infected macrophages[1]
• To study its influence on oxidative stress associated with neural cell death after hypoxia-ischemia, using neonatal hippocampal slice cultures[2]
• To quench the phosphorylation of recombinant synGA (GTPase-activating protein) induced by CaMKII[3]

Azioni biochim/fisiol

Calmodulin kinase II facilitates the calcium-dependent L-type calcium channels.[4] Autocamtide 2-related inhibitory peptide action does not influence cAMP (cyclic adenosine monophosphate)-dependent protein kinase II, calmodulin-dependent protein kinase IV and protein kinase C.[5] Increased expression of calmodulin kinase II is observed in structural heart disease, indicated by myocardial infarction. Thus, inhibition of calmodulin kinase II activity might serve as a protective effect against structural heart disease, as it is found to prevent cardiac hypertrophy, dilation and dysfunction.[6]

Potent inhibitor of calmodulin-depentent protein kinase II.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)