The S100 protein 330M-18 consists of both alpha and beta subunits. This protein belongs to the family of calcium-binding proteins, similar to calmodulin and troponin C. Specifically, S100A is composed of an alpha and beta chain, while S100B is composed of two beta chains. Furthermore, the S100 protein is expressed in antigen-presenting cells, including Langerhans cells in the skin and interdigitating reticulum cells in the paracortex of lymph nodes.
330M-1
S-100 (4C4.9) Mouse Monoclonal Antibody
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About This Item
Codice UNSPSC:
12352203
NACRES:
NA.41
Prezzi e disponibilità al momento non sono disponibili
Prodotti consigliati
Origine biologica
mouse
Livello qualitativo
100
500
Coniugato
unconjugated
Forma dell’anticorpo
diluted ascites fluid
Tipo di anticorpo
primary antibodies
Clone
4C4.9, monoclonal
Descrizione
For In Vitro Diagnostic Use in Select Regions (See Chart)
Stato
buffered aqueous solution
Reattività contro le specie
human
Confezionamento
vial of 0.1 mL concentrate (330M-14)
vial of 0.5 mL concentrate (330M-15)
bottle of 1.0 mL predilute (330M-17)
vial of 1.0 mL concentrate (330M-16)
bottle of 7.0 mL predilute (330M-18)
Produttore/marchio commerciale
Cell Marque®
tecniche
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:200
Isotipo
IgG2a
Controllo
melanoma
Condizioni di spedizione
wet ice
Temperatura di conservazione
2-8°C
Visualizzazione
cytoplasmic, nuclear
Informazioni sul gene
human ... S100A1(6271)
Categorie correlate
Descrizione generale
S-100 protein has been found in normal melanocytes, Langerhans cells, histiocytes, chondrocytes, lipocytes, skeletal and cardiac muscle, Schwann cells, epithelial and myoepithelial cells of the breast, salivary and sweat glands, as well as in glial cells.[1][2][3]Neoplasms derived from these cells also express S-100 protein, albeit non-uniformly.[1][2][4][5] A large number of well differentiated tumors of the salivary gland, adipose and cartilaginous tissue,[4] and Schwann cell-derived tumors express S-100 protein. Almost all malignant melanomas and cases of histiocytosis X are positive for S-100 protein.[5][6] Despite the fact that S-100 protein is an ubiquitous substance, its demonstration is of great value in the identification of several neoplasms, particularly melanomas.[1][2][4][5][6][3]
Qualità
 IVD |  IVD |  IVD |  RUO |
Linkage
S-100 Positive Control Slides, Product No. 330S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
Stato fisico
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
Nota sulla preparazione
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
Altre note
For Technical Service please contact: 800-665-7284 or email: [email protected]
Note legali
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
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Codice della classe di stoccaggio
12 - Non Combustible Liquids
Classe di pericolosità dell'acqua (WGK)
WGK 2
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
T Nakajima et al.
The American journal of surgical pathology, 6(8), 715-727 (1982-12-01)
The presence of S-100 protein was immunohistochemically studied in many types of formalin-fixed and paraffin-embedded tumors (260 cases). Peripheral nerve tumors, i.e., schwannomas, neurofibromas, granular cell tumors, and neurogenic sarcomas were demonstrated to contain variable amounts of S-100 protein in
L Monda et al.
Human pathology, 16(3), 287-293 (1985-03-01)
In an effort to investigate the utility of immunostaining for S-100 protein in the differential diagnosis of chondroblastoma, the expression of S-100 protein in nine chondroblastomas was compared with that in six giant cell tumors, six aneurysmal bone cysts, four
Purvisha Patel et al.
Journal of the American Academy of Dermatology, 46(2), 264-270 (2002-01-25)
Malignant myxoid melanoma (MMM) is a rarely reported variant of malignant melanoma, which can often be confused with other mucin-containing neoplasms. A retrospective study of 3 cases of MMM and a review of the English-language literature was performed. MMM affects
The immunohistochemical localization of S100 in the diagnosis of papillary carcinoma of the thyroid.
K M McLaren et al.
Human pathology, 27(7), 633-636 (1996-07-01)
In general, the diagnosis of papillary carcinoma of the thyroid is readily achieved based on a defined aggregate of histopathologic features. A papillary architecture is an important but not pivotal component of the diagnosis. The recognition of classic nuclear features
H J Kahn et al.
American journal of clinical pathology, 79(3), 341-347 (1983-03-01)
Normal tissues and various tumors were examined for S100 protein, using anti-S100 protein antiserum, in an immunoperoxidase reaction. Among normal tissues, in addition to the previously reported presence of S100 protein in some neurons, glial, and Schwann cells of the
Articoli
IHC antibodies enhance dermatopathology beyond H&E stained slides, improving techniques and applications for dermatological research.
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What are the subunits for S100 (4C4.9), 330M-18?
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