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Y0000878

Atropine

European Pharmacopoeia (EP) Reference Standard

Sinonimo/i:

Hyoscyamine, Tropine tropate, endo-(±)-α-(Hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester

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About This Item

Formula empirica (notazione di Hill):
C17H23NO3
Numero CAS:
51-55-8
Peso molecolare:
289.37
Beilstein:
91260
Numero MDL:
MFCD00022622
Codice UNSPSC:
41116107
ID PubChem:
329831200
NACRES:
NA.24

Grado

pharmaceutical primary standard

Famiglia di API

atropine

Produttore/marchio commerciale

EDQM

applicazioni

pharmaceutical (small molecule)

Formato

neat

Temperatura di conservazione

2-8°C

Stringa SMILE

CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)C(CO)c3ccccc3

InChI

1S/C17H23NO3/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3/t13-,14+,15+,16?
RKUNBYITZUJHSG-SPUOUPEWSA-N

Informazioni sul gene

human ... CHRM1(1128) , CHRM2(1129) , CHRM3(1131)

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Categorie correlate

Descrizione generale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Applicazioni

Atropine EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Azioni biochim/fisiol

Competitive nonselective antagonist at central and peripheral muscarinic acetylcholine receptors.

Confezionamento

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Altre note

Sales restrictions may apply.

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Pittogrammi

Skull and crossbones
GHS06

Avvertenze

Danger

Indicazioni di pericolo

H300 + H330

Classi di pericolo

Acute Tox. 2 Inhalation - Acute Tox. 2 Oral

Codice della classe di stoccaggio

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number

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Baptiste Berton et al.
Pharmaceutics, 12(8) (2020-08-23)
Myopia is an ophthalmic condition affecting more than 1/5th of the world population, especially children. Low-dose atropine eyedrops have been shown to limit myopia evolution during treatment. However, there are currently no commercial industrial forms available and there is little
M M McCarron et al.
Pediatrics, 87(5), 694-700 (1991-05-01)
Eight pediatric accidental overdoses of diphenoxylate-atropine (Lomotil) are reported, and 28 literature cases are reviewed. This overdose is primarily an opioid intoxication, occasionally associated with atropine toxicity. Only 6 of 36 children showed signs of atropine overdose (central nervous system
Incidence, pathophysiology, and treatment of complications during dobutamine-atropine stress echocardiography.
Marcel L Geleijnse et al.
Circulation, 121(15), 1756-1767 (2010-04-21)
D Poldermans et al.
European heart journal, 18 Suppl D, D86-D96 (1997-06-01)
Cardiac events in the peri-operative phase and late after non-cardiac vascular surgery are a major cause of morbidity and mortality. Numerous tests and diagnostic strategies--usually consisting of a combination of analysis of clinical risk factors and additional non-exercise dependent stress
Peter Jones et al.
Archives of disease in childhood, 97(2), 139-144 (2011-05-31)
Bradycardia occurs during the intubation of some critically ill children as a result of vagal stimulation due to hypoxia and/or laryngeal stimulation; such 'stable' bradycardia is accompanied by selective vasoconstriction. Some induction drugs also induce bradycardia which may be accompanied
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