Journal of neurochemistry, 126 Suppl 1, 125-141 (2013-07-24)
Friedreich's ataxia is a debilitating progressive neurodegenerative disease associated with cardiomyopathy and other features. The underlying cause is a deficiency of the mitochondrial protein frataxin which causes mitochondrial iron deposition, increased oxidative stress and impaired adenosine triphosphate production. Over the
Archives of gerontology and geriatrics, 8(3), 299-305 (1989-05-01)
The effects of idebenone on the swelling of rat brain mitochondria were studied. When FeCl3 was added to a mitochondrial suspension, a pronounced mitochondrial swelling occurred accompanied by the production of lipid peroxide; the two phenomena were closely correlated (r
Journal of neurology, 256 Suppl 1, 42-45 (2009-04-11)
Several reports in the literature describe the effects of low-dose (5 mg/kg/day) idebenone in significantly reducing cardiac hypertrophy in patients with Friedreich ataxia. However, the effects of idebenone on neurological function have not been reliably determined in these studies; when
Idebenone - monograph.
Alternative medicine review : a journal of clinical therapeutic, 6(1), 83-86 (2001-02-24)
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