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Key Documents

10171832001

Roche

Aldehyde Dehydrogenase

from yeast

Sinonimo/i:

Aldehyde dehydrogenase

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About This Item

Classificazione EC (Enzyme Commission):
Codice UNSPSC:
12352204

Origine biologica

yeast

Livello qualitativo

Forma fisica

lyophilized

Attività specifica

~20 units/mg protein (At 25 °C with acetaldehyde as the substrate.)

Confezionamento

pkg of 250 U

Produttore/marchio commerciale

Roche

pH ottimale

8.75

Malattie correlate

cancer

Temperatura di conservazione

2-8°C

Descrizione generale

Aldehyde dehydrogenase (ALDH) is a soluble enzyme and its activity depends on potassium ions and cysteine. The family of ALDH comprises of 19 genes in human. ALDH gene is expressed in the nucleus, cytosol, mitochondria and endoplasmic reticulum of the cell. ALDH is a component of nicotinamide adenine dinucleotide (NADH) and nicotinamide adenine dinucleotide phosphate (NADPH) recycling systems.

Applicazioni

Aldehyde Dehydrogenase has been used to evaluate fiber-optic biosensors for measurement of acetaldehyde (AcH) in liquid phase (AcH biosensor).

Azioni biochim/fisiol

Aldehyde dehydrogenase (ALDH) regulates the non-P450 aldehyde reduction enzyme system. It protects the cell from the effects of toxic aldehydes. Mutations in this gene are associated with Sjogren Larsson syndrome, Larsson syndrome, type II hyperprolinemia and cancer. ALDH takes part in the oxidation of aldehydes to acids. ALDH-2 lowers cardiac ischemia, which arises due to myocardial infarction or post cardiac surgery.

Qualità

Contaminants: <0.01% “NADH oxidase”, ADH, and LDH each

Stato fisico

Enzyme is stabilized with potassium phosphate buffer, pH approximately 6.

Altre note

For life science research only. Not for use in diagnostic procedures.

Pittogrammi

Exclamation markHealth hazard

Avvertenze

Warning

Indicazioni di pericolo

Classi di pericolo

Acute Tox. 4 Inhalation - STOT RE 2

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

does not flash

Punto d’infiammabilità (°C)

does not flash


Certificati d'analisi (COA)

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Yeast Aldehyde Dehydrogenase II. PROPERTIES OF THE HOMOGENEOUS ENZYME PREPARATIONS
Charles R. Steinman and WILLIAM B. JAKOBY
The Journal of Biological Chemistry, 243(4), 730-734 (1965)
Improved sensitivity of acetaldehyde biosensor by detecting ADH reverse reaction-mediated NADH fluoro-quenching for wine evaluation
Iitani K, et al.
ACS sensors, 2(7), 940-946 (2017)
Kenta Iitani et al.
Sensors (Basel, Switzerland), 23(13) (2023-07-14)
The molecule 2-nonenal is renowned as the origin of unpleasant human aging-related body odor that can potentially indicate age-related metabolic changes. Most 2-nonenal measurements rely on chromatographic analytical systems, which pose challenges in terms of daily usage and the ability
Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart
Chen CH, et al.
Science (New York, N.Y.), 321(5895), 1493-1495 (2008)
Hui Han et al.
Alcoholism, clinical and experimental research, 43(6), 1091-1102 (2019-03-26)
We previously developed enzyme nanoparticles (ENP) of alcohol metabolism. This study was to evaluate protective effects of facilitated removal of blood alcohol and/or acetaldehyde on anti-HIV drugs and alcohol-induced liver injuries. ENP were prepared for degrading alcohol completely (ENP1) or

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