MABS1198

Anti-SPINK1 Antibody, clone 4D11.1

clone 4D11.1, from mouse

• Sinonimo/i: Serine protease inhibitor Kazal-type 1, Pancreatic secretory trypsin inhibitor, TATI, Tumor-associated trypsin inhibitor
• Codice UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Proprietà

• Origine biologica: mouse
• Livello qualitativo: 100
• Forma dell’anticorpo: purified immunoglobulin
• Tipo di anticorpo: primary antibodies
• Clone: 4D11.1, monoclonal
• Reattività contro le specie: human
• tecniche: immunohistochemistry: suitable (paraffin); western blot: suitable
• Isotipo: IgG1κ
• N° accesso NCBI: NP_003113
• N° accesso UniProt: P00995
• Condizioni di spedizione: ambient
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... SPINK1(6690)

Descrizione

Descrizione generale

Serine protease inhibitor Kazal-type 1 (UniProt P00995; also known as Pancreatic secretory trypsin inhibitor, TATI, Tumor-associated trypsin inhibitor) is encoded by the SPINK1 (also known as PCTT, PSTI, TCP) gene (Gene ID 6690) in human. Serine protease inhibitor Kazal-type 1 encoded by the human SPINK1 gene functions as an acute-phase protein (APP) in the pancreas. Produced initially in a 79-a.a. proform, the signal peptide (a.a. 1-23) is removed posttranslationally to yield the 56-a.a. (a.a. 24-79) mature protein. SPINK1 protein blocks premature activation of trypsinogen (inactive form of trypsin), thereby ensuring the integrity of acinar cells to prevent auto-digestion of the pancreas. SPINK1 is also reported to play a role in tissue repair, apoptosis, reproduction, and behave as a growth factor in other human organs. In addition, SPINK1 protein is known as tumor-associated trypsin inhibitor or TATI and current research activities are focused on the association of various cancers to deregulated SPINK1 activity.

Specificità

Expected to react with both pro- and mature human SPINK1.

Immunogeno

GST-tagged recombinant human SPINK1.

Applicazioni

Anti-SPINK1, clone 4D11.1, Cat. No. MABS1198, is a highly specific mouse monoclonal antibody that targets SPINK1 and has been tested in Immunohistochemistry and Western Blotting.

Immunohistochemistry Analysis: A 1:250 dilution from a representative lot detected SPINK1 in human pancreas tissue sections.

Research Category
Signaling

Qualità

Evaluated by Western Blotting of SPINK1 GST fusion protein.

Western Blotting Analysis (WB): A 1:5000 dilution of this antibody detected 50 ng of recombinant human SPINK1 GST fusion protein.

Descrizione del bersaglio

6.247/8.507 kDa (mature/pro-form) calculated. Uncharacterized band(s) may appear in some lysates.

Stato fisico

Format: Purified

Protein G purified.

Purified mouse monoclonal IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4) 150 mM NaCl with 0.05% sodium azide.

Stoccaggio e stabilità

Stable for 1 year at 2-8°C from date of receipt.

Altre note

Concentration: Please refer to lot specific datasheet.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 12 - Non Combustible Liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable