MABF213
Anti- STING, clone 41 Antibody
clone 41, 0.5 mg/mL, from rat
Sinonimo/i:
Stimulator of interferon genes protein, mSTING, Endoplasmic reticulum interferon stimulator, ERIS, Mediator of IRF3 activation, MMITA, Transmembrane protein 173, STING
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100 μL
386,00 €
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Cambia visualizzazione
100 μL
386,00 €
About This Item
Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Prodotti consigliati
Origine biologica
rat
Livello qualitativo
Forma dell’anticorpo
purified antibody
Tipo di anticorpo
primary antibodies
Clone
41, monoclonal
Reattività contro le specie
mouse
Concentrazione
0.5 mg/mL
tecniche
flow cytometry: suitable
western blot: suitable
Isotipo
IgMκ
N° accesso NCBI
N° accesso UniProt
Condizioni di spedizione
wet ice
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
mouse ... Sting1(72512)
Categorie correlate
Descrizione generale
STING, also known as mSTING, or Endoplasmic reticulum interferon stimulator, ERIS, Mediator of IRF3 activation, MMITA or Transmembrane protein 173, and encoded by the gene Tmem 173/Eris/Mita/Mpys/Sting, is a facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferons. STING acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol. Upon binding STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state. STING also mediates cell death signaling via the activation of the ERK pathway. STING is found in multiple intracellular locations including the endoplasmic reticulum, plasma cell membrane, mitochondrion outer membrane, and perinuclear regions. STING is expressed in the B-cell lineage both immature and mature B cells but not plasma cells. Mutations in STING cause defects in innate immunity and compromised immune health.
Immunogeno
Recombinant protein corresponding to the cytoplasmic domain of mouse STING.
Applicazioni
Flow Cytometry Analysis: 2 µg of this antibody detected STING in mouse splenocyte cells.
This Anti- STING, clone 41 Antibody is validated for use in Western Blotting and Flow Cytometry for the detection of STING.
Qualità
Evaluated by Western Blotting in RAW264.7 cell lysate.
Western Blotting Analysis: A 1:2,000 dilution of this antibody detected STING in 10 µg of RAW264.7 cell lysate.
Western Blotting Analysis: A 1:2,000 dilution of this antibody detected STING in 10 µg of RAW264.7 cell lysate.
Descrizione del bersaglio
~42 kDa observed. Uniprot describes 2 isoforms produced by alternative splicing at ~38 kDa and ~48 kDa
Stato fisico
Format: Purified
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Codice della classe di stoccaggio
12 - Non Combustible Liquids
Classe di pericolosità dell'acqua (WGK)
WGK 2
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Certificati d'analisi (COA)
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Manish Chauhan et al.
Cell death & disease, 15(3), 195-195 (2024-03-09)
STING (STimulator of Interferon Genes) is a cytosolic sensor for cyclic dinucleotides (CDNs) and initiates an innate immune response upon binding to CDNs. Coxiella burnetii is a Gram-negative obligate intracellular bacterium and the causative agent of the zoonotic disease Q
Kevin MingJie Gao et al.
Cell reports, 43(4), 114114-114114 (2024-04-16)
Patients afflicted with Stimulator of interferon gene (STING) gain-of-function mutations frequently present with debilitating interstitial lung disease (ILD) that is recapitulated in mice expressing the STINGV154M mutation (VM). Prior radiation chimera studies revealed an unexpected and critical role for non-hematopoietic
Ezra B Mead et al.
Insects, 15(6) (2024-06-26)
The arbovirus West Nile virus (WNV) is a danger to global health. Spread primarily by mosquitoes, WNV causes about 2000 cases per year in the United States. The natural mosquito immune response controls viral replication so that the host survives
Assaf Marcus et al.
Immunity, 49(4), 754-763 (2018-10-18)
Detection of cytosolic DNA by the enzyme cGAS triggers the production of cGAMP, a second messenger that binds and activates the adaptor protein STING, which leads to interferon (IFN) production. Here, we found that in vivo natural killer (NK) cell killing
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