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MAB4350

Sigma-Aldrich

Anti-BMP-7 Antibody, clone 2A10

clone 2A10, from mouse

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About This Item

Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Origine biologica

mouse

Livello qualitativo

100

Forma dell’anticorpo

purified antibody

Tipo di anticorpo

primary antibodies

Clone

2A10, monoclonal

Reattività contro le specie

mouse, human

tecniche

immunohistochemistry: suitable
western blot: suitable

input

sample type mesenchymal stem cell(s)

Isotipo

IgG1κ

N° accesso UniProt

P18075

Condizioni di spedizione

wet ice

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... BMP7(655)
mouse ... Bmp7(12162)

Descrizione generale

Bone morphogenetic protein-7 (BMP-7), also known as osteogenic protein-1, is a member of the TGF- superfamily, and is widely expressed during embryonic development. Like other members of the bone morphogenetic protein family, BMP-7 works synergistically with BMP-2 to play a key role in the differentiation of mesenchymal cells into bone and cartilage tissues by actively recruiting stem cells from the surrounding tissue, thereby initiating the bone formation cascade. In adult cells, BMP-7 is predominately expressed in the brain, kidneys, and bladder.

Specificità

Reactivity with other species has not been tested.

Applicazioni

Immunohistochemistry: Recommended working dilution is 1:50.

Western Blotting: Recommended working concentration is 1 – 2 µg/mL.
This Anti-BMP-7 Antibody, clone 2A10 is validated for use in WB, IH for the detection of BMP-7.

Descrizione del bersaglio

46 kDa

Stato fisico

Format: Purified
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4),
150 mM NaCl, and 0.05% sodium azide.

Altre note

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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Codice della classe di stoccaggio

12 - Non Combustible Liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Oral administration of recombinant adeno-associated virus-mediated bone morphogenetic protein-7 suppresses CCl(4)-induced hepatic fibrosis in mice.
Hao, ZM; Cai, M; Lv, YF; Huang, YH; Li, HH
Molecular Therapy null
Rongrong Zhang et al.
Communications biology, 7(1), 266-266 (2024-03-05)
Long noncoding RNA small nucleolar RNA host gene 5 (SNHG5) is an oncogene found in various human cancers. However, it is unclear what role SNHG5 plays in activating hepatic stellate cells (HSCs) and liver fibrosis. In this study, SNHG5 was
Ariadne Cristiane Cabral Cruz et al.
Journal of applied oral science : revista FOB, 27, e20180317-e20180317 (2019-02-28)
Bone morphogenetic protein type 2 (BMP-2) and retinoic acid (RA) are osteoinductive factors that stimulate endogenous mechanisms of bone repair which can be applied on management of osseous defects in oral and maxillofacial fields. Considering the different results of RA
Ariadne Cristiane Cabral Cruz et al.
Journal of applied oral science : revista FOB, 20(6), 628-635 (2013-01-19)
Bone morphogenetic protein type 2 (BMP-2) is a potent local factor, which promotes bone formation and has been used as an osteogenic supplement for mesenchymal stem cells. This study evaluated the effect of a recombinant BMP-2 as well as the

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