ABE606

Anti-PERP Antibody

from rabbit, purified by affinity chromatography

• Sinonimo/i: p53 apoptosis effector related to PMP-22, PERP, Keratinocyte-associated protein 1, KCP-1, Krtcap1
• Codice UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Proprietà

• Origine biologica: rabbit
• Forma dell’anticorpo: affinity isolated antibody
• Tipo di anticorpo: primary antibodies
• Clone: polyclonal
• Purificato mediante: affinity chromatography
• Reattività contro le specie: human
• tecniche: immunocytochemistry: suitable; western blot: suitable
• N° accesso UniProt: A6NN79
• Condizioni di spedizione: wet ice
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... PERP(64065)

Descrizione

Descrizione generale

P53 apoptosis effector related to PMP-22 (PERP), also known as Keratinocyte-associated protein 1 (KCP-1, Krtcap1), is a member of the TMEM47 family and a component of the intercellular desmosome junctions. PERP has been shown to play an important role in the stratified epithelial integrity and cell-cell adhesion by promoting desmosome assembly. Recent evidence implies that PERP is a mediator of p53 induced apoptosis. P53 binds to the promoter of PERP and activates the PERP gene and consequently the translated PERP protein mediates the p53 induced apoptosis. PERP is expressed in apoptotic cells and in the stratified squamous skin epithelium of the skin and the tongue, but not in simple epithelia.

Immunogeno

KLH-conjugated linear peptide corresponding to human PERP.

Applicazioni

Detect P53 apoptosis effector related to PMP-22 using this rabbit polyclonal antibody, Anti-PERP Antibody validated for use in western blotting & ICC.

Immunocytochemistry Analysis: 10 µg/mL from a representative lot detected PERP in A431 cells.

Research Category
Epigenetics & Nuclear Function

Research Sub Category
RNA Metabolism & Binding Proteins

Qualità

Evaluated by Western Blotting/Peptide Inhibition Assay in A431 cell lysate.

Western Blotting/Peptide Inhibition Assay Analysis: 1 µg/mL of this antibody detected PERP in 15 µg of A431 cell lysate.

Descrizione del bersaglio

~21 kDa observed. Uncharacterized bands may appear in some lysate(s).

Stato fisico

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

Stoccaggio e stabilità

Stable for 1 year at 2-8°C from date of receipt.

Risultati analitici

Control
A431 cell lysate

Altre note

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable