648450-M

TrkA Inhibitor

The TrkA Inhibitor, also referenced under CAS 388626-12-8, controls the biological activity of TrkA. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Sinonimo/i: TrkA Inhibitor
• Formula empirica (notazione di Hill): C₁₅H₁₃N₃O₃S
• Numero CAS: 388626-12-8
• Peso molecolare: 315.35
• Codice UNSPSC: 12352200

Proprietà

• Saggio: ≥97% (sum of two isomers, HPLC)
• Forma fisica: solid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; protect from light
• Colore: yellow
• Solubilità: DMSO: 200 mg/mL
• Temperatura di conservazione: 2-8°C

Descrizione

Descrizione generale

A potent, cell-permeable, reversible, and highly selective inhibitor of TrkA (IC₅₀ = 63 nM), presumably by targeting the ATP binding pocket. Shown to exhibit ≥150-fold selectivity over Cdk1 and cRaf1.

An oxindole compound that acts as a cell-permeable, reversible, potent, and highly selective inhibitor of TrkA (IC₅₀ = 63 nM), presumably by targeting the kinase’s ATP binding pocket. Shown to exhibit ≥150-fold selectivity over Cdk1 and cRaf1.

Azioni biochim/fisiol

Primary Target
TrkA

Target IC₅₀: 63 nM against TrkA

Attenzione

Toxicity: Standard Handling (A)

Ricostituzione

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Altre note

Wood, E.R., et al. 2004. Bioorg. Med. Chem. Lett.14, 953.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable