5.05145

(+)-Tubocurarine Chloride

• Sinonimo/i: (+)-Tubocurarine Chloride, Nicotinic Acetylcholine Receptor Antagonist, (+)-Tubocurarine chloride, D-tubocurarine, DTC
• Formula empirica (notazione di Hill): C₃₇H₄₂Cl₂N₂O₆
• Numero CAS: 57-94-3
• Peso molecolare: 681.65
• Numero MDL: MFCD00013471
• Codice UNSPSC: 12352200
• NACRES: NA.77

Proprietà

• Saggio: ≥98% (HPLC)
• Livello qualitativo: 100
• Stato: solid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; protect from light
• Colore: white
• Solubilità: H₂O: soluble
• Temperatura di conservazione: −20°C
• Stringa SMILE: [Cl-].[Cl-].[N+]1([C@@H]2Cc3cc(c(cc3)O)Oc4cc5c(cc4OC)CC[N+H]([C@H]5Cc6ccc(cc6)Oc7c2c(cc(c7O)OC)CC1)C)(C)C
• InChI: 1S/C37H40N2O6.2ClH/c1-38-14-12-24-19-32(42-4)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-37-35-25(20-34(43-5)36(37)41)13-15-39(2,3)29(35)17-23-8-11-30(40)31(18-23)45-33;;/h6-11,18-21,28-29H,12-17H2,1-5H3,(H-,40,41);2*1H/t28-,29+;;/m0../s1; GXFZCDMWGMFGFL-KKXMJGKMSA-N

Descrizione

Descrizione generale

A potent competitive antagonist of nAChR (IC50= 41 nM). Used as nondepolarizing muscle relaxants during electroshock treatments, in convulsive states, and as anesthesia adjuvant.

A potent competitive antagonist of nAChR (IC₅₀ = 41 nM). Used as nondepolarizing muscle relaxants during electroshock treatments, in convulsive states, and as anesthesia adjuvant.

Azioni biochim/fisiol

Primary Target
nAch

Attenzione

Toxicity: Toxic (F)

Nota sulla preparazione

Warming is required for complete solubilization.

Ricostituzione

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Altre note

Bowman, C., 2006. Br. J. Pharmacol.147, S277.
Wenningmann, I., et al. 2001. Mol. Pharmacol.60, 790.
Pederson, X., 1990. Proc. Natl. Acad. Sci. USA.87, 2785.

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Pittogrammi: GHS06
• Avvertenze: Danger
• Indicazioni di pericolo: H300
• Consigli di prudenza: P264 - P270 - P301 + P310 - P405 - P501
• Classi di pericolo: Acute Tox. 2 Oral
• Codice della classe di stoccaggio: 6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable