Our laboratory has not validated this product for use on human JAK. However, based on the provided citation, the inhibitor appears to demonstrate effective activity on human cells as well. The study titled "Anti-adult T‑cell leukemia/lymphoma activity of cerdulatinib, a dual SYK/JAK kinase inhibitor" published in Int J Oncol. 2018 Oct;53(4):1681-1690 (PMID: 30066853) supports this observation.
420097
JAK Inhibitor I
InSolution, ≥98%
Sinonimo/i:
InSolution JAK Inhibitor I, 2-(1,1-Dimethylethyl)-9-fluoro-3,6-dihydro-7H-benz[h]-imidaz[4,5-f]isoquinolin-7-one, P6, Pyridone 6, DBI, JAK1 Inhibitor I, JAK2 Inhibitor I, JAK3 Inhibitor X
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500 μG
203,00 €
203,00 €
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Cambia visualizzazione
500 μG
203,00 €
About This Item
Formula empirica (notazione di Hill):
C18H16FN3O
Numero CAS:
Peso molecolare:
309.34
Numero MDL:
Codice UNSPSC:
12352200
NACRES:
NA.77
203,00 €
Per informazioni sulla disponibilità, contatta il Servizio Clienti.
Prodotti consigliati
Livello qualitativo
Saggio
≥98% (HPLC)
Stato
liquid
Produttore/marchio commerciale
Calbiochem®
Condizioni di stoccaggio
OK to freeze
desiccated (hygroscopic)
protect from light
Condizioni di spedizione
wet ice
Temperatura di conservazione
2-8°C
Stringa SMILE
Fc1cc2c(c3[nH]c(nc3c4c2c(ncc4)O)C(C)(C)C)cc1
InChI
1S/C18H16FN3O/c1-18(2,3)17-21-14-10-5-4-9(19)8-12(10)13-11(15(14)22-17)6-7-20-16(13)23/h4-8H,1-3H3,(H,20,23)(H,21,22)
VNDWQCSOSCCWIP-UHFFFAOYSA-N
Descrizione generale
A potent inhibitor of Janus Protein tyrosine Kinases (JAKs). Displays potent inhibitory activity against JAK1 (IC50 = 15 nM for murine JAK1), JAK2 IC50 = 1 nM), JAK3 (Ki = 5 nM), and Tyk2 (IC50 = 1 nM). It inhibits other kinases only at much higher concentrations. Also inhibits IL-2- and IL-4-dependent proliferation of CTLL cells and blocks the phosphorylation of STAT5.
Azioni biochim/fisiol
Cell permeable: yes
Primary Target
murine JAK1
murine JAK1
Product competes with ATP.
Reversible: yes
Target IC50: 15 nM, 1 nM against murine JAK1 and JAK2, respectively; 1 nM against Tyk2
Target Ki: 5 nM against JAK3
Confezionamento
Packaged under inert gas
Attenzione
Toxicity: Irritant (B)
Stato fisico
A 10 mM (500 µg/162 µl) solution of JAK Inhibitor I (Cat. No. 420099) in DMSO.
Ricostituzione
Following initial use, aliquot and refrigerate (4°C).
Altre note
Thompson, J.E., et al. 2002. Bioorg. Med. Chem. Lett.12, 1219.
Note legali
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
WGK 2
Punto d’infiammabilità (°F)
188.6 °F - closed cup - (Dimethylsulfoxide)
Punto d’infiammabilità (°C)
87 °C - closed cup - (Dimethylsulfoxide)
Certificati d'analisi (COA)
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
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Can the InSolution JAK Inhibitor I - CAS 457081-03-7 - Calbiochem also target human JAK, considering that its primary target is stated as murine? I am in search of an inhibitor for human JAK.
1 risposta-
Utile?
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Filtri attivi
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