400076-M

Hypericin

Polycyclic dione that has anti-retroviral activity.

• Sinonimo/i: Hypericin, Casein Kinase II Inhibitor XI
• Formula empirica (notazione di Hill): C₃₀H₁₆O₈
• Numero CAS: 548-04-9
• Peso molecolare: 504.44
• Numero MDL: MFCD00016683
• Codice UNSPSC: 12352200

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Forma fisica: solid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; protect from light
• Colore: black
• Solubilità: ethanol: 1 mg/mL; methanol: 1 mg/mL; DMSO: 10 mg/mL
• Temperatura di conservazione: 2-8°C
• InChI: 1S/C30H16O8/c1-7-3-9(31)19-23-15(7)16-8(2)4-10(32)20-24(16)28-26-18(12(34)6-14(36)22(26)30(20)38)17-11(33)5-13(35)21(29(19)37)25(17)27(23)28/h3-6,31-36H,1-2H3; BTXNYTINYBABQR-UHFFFAOYSA-N

Descrizione

Descrizione generale

Polycyclic dione that has anti-retroviral activity. Inhibits protein kinase C (IC₅₀ = 3.3 µM). Also known to inhibit the protein tyrosine kinase activities of the insulin receptor (IC₅₀ = 20-29 nM), the epidermal growth factor receptor (IC₅₀ = 35 nM), casein kinase II (IC₅₀ = 6 nM), and MAP kinase (IC₅₀ = 4 nM). Useful probe for PKC due to its bright red fluorescence emission and photostability. Also see Pseudohypericin (Cat. No. 539590).

Polycyclic dione that has anti-retroviral activity. Inhibits protein kinase C (IC₅₀ = 3.3 μM). Also known to inhibit casein kinase II (IC₅₀ = 6 nM), MAP kinase (IC₅₀ = 4 nM), and the protein tyrosine activities of the insulin receptor (IC₅₀ = 20-29 nM) and the epidermal growth factor receptor (IC₅₀ = 35 nM).

Azioni biochim/fisiol

Primary Target
PKC

Target IC₅₀: 3.3 µM, 6 nM, 4 nM, 20-29 nM , 35 nM, against protein kinase C, casein kinase II, MAP kinase, the protein tyrosine activities of the insulin receptor, and the epidermal growth factor receptor, respectively

Attenzione

Toxicity: Harmful (C)

Ricostituzione

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Altre note

Zhang, W., et al. 1997. Cancer Lett.120, 31.
Agostinis, P., et al. 1995. Biochem. Pharmacol.49, 1615.
Frew, T., et al. 1994. Anticancer Res.14, 2425.
Barnard, D.L., et al. 1992. Antiviral Res.17, 63.
Takahashi, I., et al. 1989. Biochem. Biophys. Res. Commun.165, 1207.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H302
• Consigli di prudenza: P264 - P270 - P301 + P312 - P501
• Classi di pericolo: Acute Tox. 4 Oral
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable