218759
Caspase-8 Inhibitor II
≥98% (HPLC), powder, Caspase-8 inhibitor, Calbiochem®
Sinonimo/i:
Caspase-8 Inhibitor II, Z-IE(OMe)TD(OMe)-FMK, Granzyme B Inhibitor III
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About This Item
Formula empirica (notazione di Hill):
C30H43FN4O11
Peso molecolare:
654.68
Codice UNSPSC:
12352200
NACRES:
NA.77
Prodotti consigliati
product name
Caspase-8 Inhibitor II, The Caspase-8 Inhibitor II controls the biological activity of Caspase-8. This small molecule/inhibitor is primarily used for Cancer applications.
Livello qualitativo
Forma fisica
powder
Produttore/marchio commerciale
Calbiochem®
Condizioni di stoccaggio
OK to freeze
desiccated
Colore
white to yellow
Solubilità
DMSO: 10 mM
Condizioni di spedizione
ambient
Temperatura di conservazione
−20°C
Descrizione generale
A potent, cell-permeable, and irreversible inhibitor of caspase-8 (MACH, FLICE, Mch5). Also inhibits granzyme B.
A potent, cell-permeable, and irreversible inhibitor of caspase-8 and granzyme B. Effectively inhibits influenza virus-induced apoptosis in HeLa cells. Also inhibits granzyme B. When using with purified native or recombinant enzyme, pretreatment with an esterase is required. A 5 mM (250 µg/76 µl) solution of Z-IETD-FMK (Cat. No. 218840) in DMSO is also available.
Azioni biochim/fisiol
Cell permeable: yes
Primary Target
caspase-8
caspase-8
Product does not compete with ATP.
Reversible: no
Attenzione
Toxicity: Standard Handling (A)
Sequenza
Z-Ile-Glu(OMe)-Thr-Asp(OMe)-CH₂F*
Ricostituzione
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 8 months at -20°C.
Risultati analitici
≥98% (HPLC)
Altre note
Takizawa, T., et al. 1999. Microbiol. Immunol.43, 245.
Martin, D.A., et al. 1998. J. Biol. Chem.273, 4345.
Sweeney, E.A., et al. 1998. FEBS Lett.425, 61.
Thornberry, N.A., and Lazebnik, Y. 1998. Science281, 1312.
Martin, D.A., et al. 1998. J. Biol. Chem.273, 4345.
Sweeney, E.A., et al. 1998. FEBS Lett.425, 61.
Thornberry, N.A., and Lazebnik, Y. 1998. Science281, 1312.
Note legali
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Certificati d'analisi (COA)
Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.
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