20-133-M
PKC Lipid Activator
Sinonimo/i:
PKC activator, Protein kinase C activator
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About This Item
Codice UNSPSC:
41116012
eCl@ss:
32160405
NACRES:
NA.41
Prodotti consigliati
Forma fisica
liquid
Livello qualitativo
Produttore/marchio commerciale
Upstate®
tecniche
activity assay: suitable (kinase)
N° accesso NCBI
N° accesso UniProt
Informazioni sul gene
human ... PRKCA(5578)
Descrizione generale
Protein kinase C (PKC) belongs to a family of serine/ threonine kinases. It comprises a regulatory domain at the N-terminus and a catalytic domain at the C-terminus. The regions are divided into conserved regions (C1–C4) and regions that differ between isoforms (V1–V5). PKC has a common pseudosubstrate domain in the regulatory region.
Applicazioni
For use in kinase assays.
Research Category
All
All
Azioni biochim/fisiol
Protein kinase C (PKC) is activated by diacylglycerol (DAG) and acts as an intracellular receptor of tumor-promoting phorbol esters. It regulates several cell functions and signal transduction pathways through cell migration and polarity, differentiation, proliferation, and cell death. PKC is part of a large group of phospholipid-dependent enzymes, which catalyze the covalent transfer of phosphate from ATP to serine and threonine residues of proteins.
Stato fisico
20mM MOPS, pH 7.2, 25mM β-glycerolphosphate, 1mM sodium orthovanadate, 1mM dithiothreitol, 1mM CaCl2.
Stoccaggio e stabilità
1 year at -20°C
Note legali
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Codice della classe di stoccaggio
12 - Non Combustible Liquids
Classe di pericolosità dell'acqua (WGK)
WGK 2
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Certificati d'analisi (COA)
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
D Breitkreutz et al.
Journal of cancer research and clinical oncology, 133(11), 793-808 (2007-07-31)
The protein kinase C (PKC) family represents a large group of phospholipid dependent enzymes catalyzing the covalent transfer of phosphate from ATP to serine and threonine residues of proteins. Phosphorylation of the substrate proteins induces a conformational change resulting in
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