The optimal working concentration of the product is cell type and application dependent. Typically, a working concentration in the range of 0.5 to 2 uM is recommended.
189825
5-Aza-2′-Deoxycytidine
A cytosine analog that acts as a DNA methyltransferase inhibitor.
Sinonimo/i:
5-Aza-2′-Deoxycytidine, 5-Aza-CdR, 5-Aza-dC, 2′-Deoxy-5-azacytidine, Decitabine
Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali
Scegli un formato
25 MG
426,00 €
426,00 €
Spedizione prevista il18 aprile 2025Dettagli
Scegli un formato
Cambia visualizzazione
25 MG
426,00 €
About This Item
Formula empirica (notazione di Hill):
C8H12N4O4
Numero CAS:
Peso molecolare:
228.21
Numero MDL:
Codice UNSPSC:
12352208
NACRES:
NA.77
426,00 €
Spedizione prevista il18 aprile 2025Dettagli
Prodotti consigliati
Livello qualitativo
Descrizione
RTECS - XZ3012000
Saggio
≥98% (HPLC)
Stato
lyophilized
Produttore/marchio commerciale
Calbiochem®
Condizioni di stoccaggio
OK to freeze
Solubilità
methanol: 1 mg/mL
50% acetic acid: 25 mg/mL
DMSO: 25 mg/mL
Condizioni di spedizione
ambient
Temperatura di conservazione
2-8°C
Stringa SMILE
N2(C=NC(=N)NC2=O)C1OC(C(C1)O)CO
InChI
1S/C8H12N4O4/c9-7-10-3-12(8(15)11-7)6-1-4(14)5(2-13)16-6/h3-6,13-14H,1-2H2,(H2,9,11,15)
XAUDJQYHKZQPEU-UHFFFAOYSA-N
Descrizione generale
A cytosine analog that acts as a DNA methyltransferase inhibitor. Restores caspase-8 and caspase-10 mRNA and protein expression as well as TRAIL (Tumor necrosis factor-Related Apoptosis Inducing Ligand) sensitivity in TRAIL-resistant cell lines. Also enhances apoptosis induced by HDAC (Histone Deacetylase) inhibitors. Also available as a 100 mM solution in DMSO (Cat. No. 189826).
Azioni biochim/fisiol
Primary Target
DNA methyltransferase inhibitor
DNA methyltransferase inhibitor
Confezionamento
Packaged under inert gas
Attenzione
Toxicity: Harmful & Carcinogenic / Teratogenic (E)
Nota sulla preparazione
warming is required to achieve complete solubilization
Ricostituzione
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Altre note
Eggert, A., et al. 2001. Cancer Res.61, 1314.
Takebayashi, S., et al. 2001. Biochem. Biophys. Res. Commun.288, 921.
Zhu, W.G., et al. 2001. Cancer Res.61, 1327.
Hopkins-Donaldson, S., et al. 2000. Cancer Res.60, 4315.
Haaf, T. 1995. Pharmacol. Ther.65, 19.
Jones, P.A., and Taylor, S.M. 1980. Cell20, 85.
Takebayashi, S., et al. 2001. Biochem. Biophys. Res. Commun.288, 921.
Zhu, W.G., et al. 2001. Cancer Res.61, 1327.
Hopkins-Donaldson, S., et al. 2000. Cancer Res.60, 4315.
Haaf, T. 1995. Pharmacol. Ther.65, 19.
Jones, P.A., and Taylor, S.M. 1980. Cell20, 85.
Note legali
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Avvertenze
Danger
Indicazioni di pericolo
Consigli di prudenza
Classi di pericolo
Acute Tox. 4 Oral - Eye Irrit. 2 - Muta. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3
Organi bersaglio
Respiratory system
Codice della classe di stoccaggio
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Classe di pericolosità dell'acqua (WGK)
WGK 3
Certificati d'analisi (COA)
Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.
Possiedi già questo prodotto?
I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
I clienti hanno visto anche
Bin Xie et al.
Cell biology international, 46(11), 1900-1914 (2022-08-23)
Ras-association domain family 1A (RASSF1A) is one of the most methylated genes in lung cancer (LC). We investigate whether the high DNA methylation level of RASSF1A can relieve the resistance of RASSF1A to LC by inhibiting RASSF1A's transcription factor binding
Jingjing Du et al.
Gut microbes, 13(1), 1-19 (2021-02-09)
Betaine is a natural compound present in commonly consumed foods and may have a potential role in the regulation of glucose and lipids metabolism. However, the underlying molecular mechanism of its action remains largely unknown. Here, we show that supplementation
Carl M Gay et al.
Cancer cell, 39(3), 346-360 (2021-01-23)
Despite molecular and clinical heterogeneity, small cell lung cancer (SCLC) is treated as a single entity with predictably poor results. Using tumor expression data and non-negative matrix factorization, we identify four SCLC subtypes defined largely by differential expression of transcription
Jia-Xue Sun et al.
Epigenetics, 19(1), 2337087-2337087 (2024-04-02)
Decidual macrophages are the second-largest immune cell group at the maternal-foetal interface. They participate in apoptotic cell removal, and protect the foetus from microorganisms or pathogens. Dysfunction of decidual macrophages gives rise to pregnancy complications such as preeclampsia and recurrent
Adam W Watson et al.
Cell reports, 35(13), 109293-109293 (2021-07-01)
While the immediate and transitory response of breast cancer cells to pathological stiffness in their native microenvironment has been well explored, it remains unclear how stiffness-induced phenotypes are maintained over time after cancer cell dissemination in vivo. Here, we show that
-
Please provide a brief idea of how much 5-Aza-2ʹ-Deoxycytidine must be added to cell culture to yield the best results with product number 189825-25MG?
1 risposta-
Utile?
-
Filtri attivi
Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..
Contatta l'Assistenza Tecnica.
