1.08212

Poloxamer 188

(stabilized with 70ppm BHT), EMPROVE^® ESSENTIAL, Ph. Eur., NF

• Sinonimo/i: Poloxamer 188
• Formula condensata: (C₃H₆O · C₂H₄O)_x
• Numero CAS: 9003-11-6
• Numero MDL: MFCD00082049
• Codice UNSPSC: 12352112

Proprietà

• Origine biologica: synthetic
• Livello qualitativo: 500
• agenzia: NF; Ph. Eur.
• Nome Commerciale: EMPROVE^® ESSENTIAL
• P. eboll.: >150 °C
• Punto di fusione: 55 °C
• Densità bulk: 1050 kg/m³
• Temperatura di conservazione: 2-25°C
• InChI: 1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2; RVGRUAULSDPKGF-UHFFFAOYSA-N

Descrizione

Descrizione generale

With formulation challenges in mind, we have used particle engineering technologies to develop functional excipients specifically for solid oral dosage forms. The products in our Parteck^® portfolio feature unique particle properties tailored for excellent performance in tableting processes, for specific drug delivery technologies, or for solubility enhancement.
As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Applicazioni

Parteck^® PLX 188 excipient combines adequate lubrication at tolerable concentrations with the added benefit of dissolution enhancement. It features consistent performance, improved dissolution rate and reliable lubrication – all at the same time. As a result, Parteck^® PLX 188 excipient can therefore provide a simple solution to low bioavailability of DCS 2a compounds.

Caratteristiche e vantaggi

• Hydrophilic, water-soluble tablet lubrication
• Improved dissolution rates for poorly soluble DCS class IIa molecules
• Specified particle size distribution optimized for solid application performance
• Regulatory support through compliance with Ph. Eur. and USP-NF, going beyond current requirements with specitied formaldehyde content

Note legali

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

PARTECK is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable