N-073

Nimetazepam solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

• Formula empirica (notazione di Hill): C₁₆H₁₃N₃O₃
• Numero CAS: 2011-67-8
• Peso molecolare: 295.29
• Numero MDL: MFCD00242916
• Codice UNSPSC: 41116107
• ID PubChem: 329818453
• NACRES: NA.24

Proprietà

• Grado: certified reference material
• Forma fisica: liquid
• Caratteristiche: Snap-N-Spike^®/Snap-N-Shoot^®
• Confezionamento: ampule of 1 mL
• Produttore/marchio commerciale: Cerilliant^®
• drug control: Narcotic Licence Schedule B (Switzerland); psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)
• Concentrazione: 1.0 mg/mL in methanol
• tecniche: gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• applicazioni: clinical testing
• Formato: single component solution
• Temperatura di conservazione: −20°C
• Stringa SMILE: CN1C(=O)CN=C(c2ccccc2)c3cc(ccc13)[N+]([O-])=O
• InChI: 1S/C16H13N3O3/c1-18-14-8-7-12(19(21)22)9-13(14)16(17-10-15(18)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3; GWUSZQUVEVMBPI-UHFFFAOYSA-N

Descrizione

Descrizione generale

Nimetazepam, marketed as the benzodiazepine drug Erimin, is prescribed for the treatment of stress or short-term severe insomnia in patients who have difficulty falling asleep or maintaining sleep. Cases of abuse have been reported from Southeast Asian countries including Thailand, Malaysia, Singapore, and Hong Kong to states such as Alabama and North Carolina. Although not used therapeutically in the US, the drug is known for its use to soften the comedown after use of methamphetamine or other stimulants.

Applicazioni

• Advanced Analytical Techniques for Benzodiazepines: Nimetazepam has been included in studies using ultra-high performance liquid chromatography coupled with high-resolution time-of-flight mass spectrometry. This methodology is pivotal for the precise analysis of designer benzodiazepines and their pharmacokinetic properties, enhancing research in sedative biochemical studies and psychoactive drug research (Tomková et al., 2017).


• Forensic and Clinical Toxicology: Development and validation of gas chromatography-mass spectrometry methods for benzodiazepine drugs, including nimetazepam, highlight its application in both clinical and forensic toxicology. This approach facilitates the accurate detection and quantification of benzodiazepines in biological specimens, aiding in the management of conditions such as sleep disorders and anxiety (Papoutsis et al., 2010).

Note legali

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Pittogrammi: GHS02,GHS06,GHS08
• Avvertenze: Danger
• Indicazioni di pericolo: H225,H301 + H311 + H331,H370
• Consigli di prudenza: P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311
• Classi di pericolo: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• Organi bersaglio: Eyes
• Codice della classe di stoccaggio: 3 - Flammable liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): 49.5 °F - closed cup
• Punto d’infiammabilità (°C): 9.7 °C - closed cup