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860058P

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Ganglioside GM3 (Bovine Milk)

Avanti Research™ - A Croda Brand

Sinonimo/i:

110953

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About This Item

Numero CAS:
1246353-19-4
Codice UNSPSC:
12352211
NACRES:
NA.25

Descrizione

GM3 Ganglioside (Milk, Bovine-Ammonium Salt)

Saggio

>99% (TLC)

Forma fisica

powder

Confezionamento

pkg of 1 × 1 mg (860058P-1mg)
pkg of 1 × 10 mg (860058P-10mg)
pkg of 1 × 25 mg (860058P-25mg)
pkg of 1 × 5 mg (860058P-5mg)

Produttore/marchio commerciale

Avanti Research™ - A Croda Brand

Tipo di lipide

sphingolipids

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

Stringa SMILE

[H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@@]([H])(NC(CCCCCCCCCCCCCCCCC)=O)CO[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@@H]2O[C@H](CO)[C@@H]([C@H](O[C@@]3(C([O-])=O)O[C@@H]([C@H](O)[C@H](O)CO)[C@@](NC(C)=O)([H])[C@@H](O)C3)[C@H]2O)O)[C@@H](CO)O1.[NH4+]

Descrizione generale

Ganglioside monosialodihexosylganglioside (GM3) are glycosphingolipids (GSLs), which are membrane-bound consisting of a sialic acid residue and an oligosaccharide head structure. It is found in milk and kidney cells. GM3 is the most broadly distributed ganglioside in tissues.

Applicazioni

Ganglioside GM3 (Bovine Milk) has been used in lipid binding assay to assess the binding of monoclonal antibodies (mAbs). It may be used as a standard to investigate the efficiency of ganglioside extraction in brain using electrospray ionization-mass spectrometry (ESI MS) analysis. It may also be used for the structural characterization of gangliosides using ultraviolet photodissociation mass spectrometry.

Azioni biochim/fisiol

Ganglioside monosialodihexosylganglioside (GM3) blocks the activity of fibroblast growth factor receptor. GM3-enriched microdomain is involved in modulating cell growth. Low levels of ganglioside GM3 is involved in the pathogenesis of rheumatoid arthritis. GM3 regulates immunological functions by preventing cytokine production. It regulates apoptosis, cell proliferation and differentiation. GM3 is also involved in cellular signaling pathways, cell adhesion and mobility. Increased GM3 levels are associated with diabetic nephropathy.

Confezionamento

5 mL Amber Glass Screw Cap Vial (860058P-10mg)
5 mL Amber Glass Screw Cap Vial (860058P-1mg)
5 mL Amber Glass Screw Cap Vial (860058P-25mg)
5 mL Amber Glass Screw Cap Vial (860058P-5mg)

Note legali

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Comunemente ordinati con questo prodotto

N° Catalogo
Descrizione
Determinazione del prezzo

Codice della classe di stoccaggio

11 - Combustible Solids

Certificati d'analisi (COA)

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Sigma-Aldrich

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FSL-A(tri)

Sigma-Aldrich

F9307

FSL-A(tri)

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Sigma-Aldrich

G9652

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Peptone Pancreatic digest of casein, suitable for microbiology

Millipore

70169

Peptone

John P O'Brien et al.
Analytical chemistry, 85(21), 10399-10407 (2013-10-03)
Ultraviolet photodissociation (UVPD) mass spectrometry was used to characterize the structures of amphiphilic glycosphingolipids and gangliosides in comparison to collision induced dissociation (CID) and higher energy collision dissociation (HCD) in a high performance Orbitrap mass spectrometer. UVPD produced the widest
Igor Vukovic et al.
Kidney & blood pressure research, 40(3), 306-314 (2015-06-06)
Despite scientific advances, diabetic nephropathy remains both a therapeutical challenge, and one of the major diabetic complications. Chemical structure of gangliosides, the most complex of glycosphingolipids, is characterised by one or more sialic acids and carbohydrate groups linked to a
Yukinori Tsukuda et al.
PloS one, 7(6), e40136-e40136 (2012-07-07)
Rheumatoid arthritis (RA), a chronic systemic inflammatory disorder that principally attacks synovial joints, afflicts over 2 million people in the United States. Interleukin (IL)-17 is considered to be a master cytokine in chronic, destructive arthritis. Levels of the ganglioside GM3
Sonia Tomar et al.
Glycoconjugate journal (2019-12-06)
Sialidases or neuraminidases play important roles in various physiological and pathological processes by cleaving terminal sialic acids (Sias) (desialylation) from the glycans of both glycoproteins and glycolipids. To understand the biological significance of desialylation by sialidases, it is important to
Thomas Kolter
ISRN biochemistry, 2012, 506160-506160 (2012-01-01)
Gangliosides are sialic acid-containing glycosphingolipids. They occur especially on the cellular surfaces of neuronal cells, where they form a complex pattern, but are also found in many other cell types. The paper provides a general overview on their structures, occurrence
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