857328P

18:1 Cyclic LPA

1-oleoyl-sn-glycero-2,3-cyclic-phosphate (ammonium salt), powder

• Sinonimo/i: 1-(9Z-octadecenoyl)-sn-glycero-2,3-cyclic-phosphate (ammonium salt)
• Formula empirica (notazione di Hill): C₂₁H₄₂NO₆P
• Numero CAS: 799268-72-7
• Peso molecolare: 435.54
• Codice UNSPSC: 51191904
• NACRES: NA.25

Proprietà

• Saggio: >99% (TLC)
• Stato: powder
• Confezionamento: pkg of 1 × 1 mg (857328P-1mg)
• Produttore/marchio commerciale: Avanti Research^™ - A Croda Brand 857328P
• Tipo di lipide: cardiolipins; phospholipids
• Condizioni di spedizione: dry ice
• Temperatura di conservazione: −20°C
• Stringa SMILE: O=C(CCCCCCC/C=C\CCCCCCCC)OC[C@@H]1COP(O1)([O-])=O.[NH4+]
• InChI: 1S/C21H39O6P.H3N/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(22)25-18-20-19-26-28(23,24)27-20;/h9-10,20H,2-8,11-19H2,1H3,(H,23,24);1H3/b10-9-;/t20-;/m1./s1; BQDHONSGIYYBPK-JGSYTFBMSA-N

Descrizione

Descrizione generale

Cyclic phosphatidic acid (cPA) is a naturally occurring analog of the growth factor-like phospholipid mediator, lysophosphatidic acid (LPA). The sn-2 hydroxy group of CPA forms a 5-membered ring with the sn-3 phosphate. cPA affects numerous cellular functions, including anti-mitogenic regulation of the cell cycle,[1] induction of stress fiber formation,[2] inhibition of tumor cell invasion and metastasis,[3] and regulation of differentiation and survival of neuronal cells.[4]
Interestingly, many of these cellular responses caused by cPA oppose those of LPA despite the activation of apparently overlapping receptor populations.

Applicazioni

18:1 Cyclic LPA has been used for the preparation of liposomes.[5] It has also been used for the extraction recovery of cyclic phosphatidic acid (cPA) at different pH conditions using Bligh−Dyer method.[6]

Confezionamento

5 mL PTFE Vial with Screw Cap (857328P-1mg)

Note legali

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3