850185P

08:0 PI(4,5)P2

Avanti Research^™ - A Croda Brand

• Sinonimo/i: PIP2[4′,5′](8:0/8:0); 110665
• Formula empirica (notazione di Hill): C₂₅H₅₈N₃O₁₉P₃
• Numero CAS: 852043-37-9
• Peso molecolare: 797.66
• Codice UNSPSC: 51191904
• NACRES: NA.25

Proprietà

• Descrizione: 1,2-dioctanoyl-sn-glycero-3-phospho-(1′-myo-inositol-4′,5′-bisphosphate) (ammonium salt)
• Saggio: >99% (TLC)
• Stato: powder
• Confezionamento: pkg of 1 × 100 μg (with stopper and crimp cap (850185P-100ug)); pkg of 1 × 500 μg (with stopper and crimp cap (850185P-500ug))
• Produttore/marchio commerciale: Avanti Research^™ - A Croda Brand
• Tipo di lipide: cardiolipins; phospholipids
• Condizioni di spedizione: dry ice
• Temperatura di conservazione: −20°C
• Stringa SMILE: [H][C@@](COP([O-])(O[C@H]1[C@H](O)[C@@H](OP(O)([O-])=O)[C@H](OP([O-])(O)=O)[C@@H](O)[C@H]1O)=O)(OC(CCCCCCC)=O)COC(CCCCCCC)=O.[NH4+].[NH4+].[NH4+]
• InChI: 1S/C25H49O19P3.3H3N/c1-3-5-7-9-11-13-18(26)39-15-17(41-19(27)14-12-10-8-6-4-2)16-40-47(37,38)44-23-20(28)21(29)24(42-45(31,32)33)25(22(23)30)43-46(34,35)36;;;/h17,20-25,28-30H,3-16H2,1-2H3,(H,37,38)(H2,31,32,33)(H2,34,35,36);3*1H3/t17-,20-,21+,22+,23-,24-; FRWPUPUJRUQWKA-OZTQGENFSA-N

Descrizione

Descrizione generale

Although PI(4,5)P2 is a minor component of cell membranes, it plays a critical role as a substrate for a number of important signaling proteins. PI(4,5)P2 is an intermediate in the IP3/DAG pathway where it is hydrolyzed by phospholipase C to liberate the second messengers, inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). PI(4,5)P2 is also a substrate for PI 3-kinase where it is phosphorylated to PI(3,4,5)P3, an activator of downstream signaling components such as the protein kinase AKT. The dioctanoyl derivative of PI(4,5)P2 is more water soluble than its long chain counterparts.

Applicazioni

08:0 PI(4,5)P2 is suitable for use to identify its binding site in transient receptor potential vanilloid 4 (TRPV4 N) terminus.[1] It has been used in in vitro binding assay to determine the binding of G-protein coupled receptor kinases (GRKs) and β2-adrenergic receptor (β₂AR).[2]

Confezionamento

2 mL Amber Serum Vial with Stopper and Crimp Cap (850185P-100ug)

2 mL Amber Serum Vial with Stopper and Crimp Cap (850185P-500ug)

Note legali

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids