700040P
Avanti
desmosterol-d6
Avanti Research™ - A Croda Brand
Sinonimo/i:
24-dehydrocholesterol(d6); 5,24-cholestadien-3β-ol(d6)
Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali
Scegli un formato
1 MG
450,00 €
Scegli un formato
Cambia visualizzazione
1 MG
450,00 €
About This Item
Formula empirica (notazione di Hill):
C27H38OD6
Numero CAS:
Peso molecolare:
390.67
Numero MDL:
Codice UNSPSC:
12352100
NACRES:
NA.25
Prodotti consigliati
Descrizione
cholesta-5,24-dien-3β-ol-d6
Saggio
>99% (TLC)
Stato
powder
Confezionamento
pkg of 1 × 1 mg (700040P-1mg)
Produttore/marchio commerciale
Avanti Research™ - A Croda Brand
Condizioni di spedizione
dry ice
Temperatura di conservazione
−20°C
Descrizione generale
Applicazioni
Desmosterol-d6 has been used:
- as a deuterated standard in liquid chromatography multiple reaction monitoring (LC-MRM)[3]
- as a deuterated standard in high-performance liquid chromatography/electrospray ionization tandem mass spectrometry (HPLC-ESI-MS)[4]
- for spiking brain tissue homogenate from Alzheimer′s disease (AD) for liquid chromatography -mass spectrometry (LC-MS) analysis[5]
Azioni biochim/fisiol
Desmosterol low levels in the hippocampus directly impacts progenitor cell differentiation into neurons.[1] Desmosterol-d6 is used as a substitute to desmosterol in hepatitis C virus (HCV) based viral assays to rescue replication.[2] Desmosterol being a C27 sterol intermediate is implicated in the Alzheimer′s disease (AD) pathogenesis.[5]
Confezionamento
5 mL Amber Glass Screw Cap Vial (700040P-1mg)
Note legali
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Comunemente ordinati con questo prodotto
N° Catalogo
Descrizione
Determinazione del prezzo
Codice della classe di stoccaggio
11 - Combustible Solids
Scegli una delle versioni più recenti:
Certificati d'analisi (COA)
Lot/Batch Number
It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documenti section.
Se ti serve aiuto, non esitare a contattarci Servizio Clienti
Possiedi già questo prodotto?
I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
Yoshiaki Sato et al.
Alzheimer's & dementia (Amsterdam, Netherlands), 1(1), 67-74 (2015-03-01)
We here examined whether plasma desmosterol-to-cholesterol ratio (DES/CHO) is decreased in patients with Alzheimer's disease (AD) and investigated the association between plasma DES/CHO and longitudinal cognitive decline. Plasma DES/CHO of AD patients and age-matched controls in a Japanese cross-sectional cohort
Valerie A Villareal et al.
ACS chemical biology, 11(7), 1827-1833 (2016-04-30)
Hepatitis C virus (HCV) increases intracellular desmosterol without affecting the steady-state abundance of other sterols, and the antiviral activity of inhibitors of desmosterol synthesis is suppressed by the addition of exogenous desmosterol. These observations suggest a model in which desmosterol
Thomas Wisniewski et al.
Journal of Alzheimer's disease : JAD, 33(3), 881-888 (2012-10-09)
Desmosterol is a C27 sterol intermediate in cholesterol synthesis generated during the metabolic pathway that transforms lanosterol into cholesterol. It has become of particular interest in the pathogenesis of Alzheimer's disease (AD) because of the report that the activity of
Jeffrey G McDonald et al.
Methods in enzymology, 432, 145-170 (2007-10-24)
We describe the development of a high performance liquid chromatography mass spectrometry (HPLC-MS) method that allows the identification and quantitation of sterols in mammalian cells and tissues. Bulk lipids are extracted from biological samples by a modified Bligh/Dyer procedure in
Priyadarshini Chakrabarti et al.
Metabolomics : Official journal of the Metabolomic Society, 15(10), 127-127 (2019-09-21)
Significant annual honey bee colony losses have been reported in the USA and across the world over the past years. Malnutrition is one among several causative factors for such declines. Optimal nutrition serves as the first line of defense against
Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..
Contatta l'Assistenza Tecnica.
